Gap 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 9.00 (6 x 10: ৳ 540.00)
Strip Price: ৳ 90.00

Medicine Details

Category Details
Generic Omeprazole
Company Euro pharma ltd
Also available as
Gap 20 mg capsule Gap 40 mg injection

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of the antisecretory effect occurs within one hour
  • Maximum effect occurs within two hours
  • Inhibition of secretion lasts up to 72 hours
  • Secretory activity returns gradually over 3 to 5 days after discontinuation

Dosage

  • 20 mg once daily for benign gastric and duodenal ulcer
  • 20 mg once daily for NSAID-associated duodenal or gastric ulcer
  • 20 mg once daily for gastro-esophageal reflux disease
  • 10-20 mg daily for long-term management of acid reflux disease
  • 10-20 mg once daily for acid-related dyspepsia
  • 40 mg on the preceding evening and then 40 mg 2-6 hours before surgery for prophylaxis of acid aspiration
  • Initially 60 mg once daily for Zollinger-Ellison syndrome
  • Omeprazole is recommended at a dose of 20 mg twice daily in association with antimicrobial agents for Helicobacter pylori eradication regimen
  • Pediatric use in severe ulcerating reflux esophagitis: 10-40 mg once daily depending on body weight

Administration

  • IV Injection: Given slowly over a period of 5 minutes as an intravenous injection
  • IV Infusion: Given as an intravenous infusion over a period of 20-30 minutes or more
  • Reconstituted solution should be used within specific timeframes
  • IV injection should be given as a slow intravenous injection

Interaction

  • Decreased intragastric acidity may reduce the absorption of ketoconazole
  • Metabolised in the liver through cytochrome P450
  • Can delay the elimination of diazepam, phenytoin, and warfarin
  • Plasma concentrations of Omeprazole and clarithromycin are increased during concomitant administration

Contraindications

  • Known hypersensitivity to Omeprazole
  • Suspicion of gastric ulcer with the possibility of malignancy

Side Effects

  • Skin rash, urticaria, and pruritus
  • Photosensitivity, bullous eruption, and erythema multiforme
  • Diarrhoea, headache
  • Constipation, nausea/vomiting, flatulence, and abdominal pain
  • Dry mouth, stomatitis, and candidiasis

Pregnancy & Lactation

  • Results from prospective epidemiological studies indicate no adverse effects on pregnancy or the health of the fetus/newborn child
  • Breastfeeding should be discontinued if the use of Omeprazole is considered essential

Precautions & Warnings

  • Avoid concomitant use of clopidogrel and Omeprazole
  • Observational studies suggest PPI therapy may be associated with an increased risk for osteoporosis-related fractures

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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