Piazol 20 mg (Capsule (Enteric Coated))
Unit Price: ৳ 5.00 (60's pack: ৳ 300.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Omeprazole |
| Company | Globex pharmaceuticals ltd |
Indications
- Gastric and duodenal ulcer
- NSAID-associated duodenal and gastric ulcer
- As prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
- Gastro-esophageal reflux disease
- Long-term management of acid reflux disease
- Acid-related dyspepsia
- Severe ulcerating reflux esophagitis
- Prophylaxis of acid aspiration during general anesthesia
- Zollinger-Ellison syndrome
- Helicobacter pylori-induced peptic ulcer
Pharmacology
- Inhibitor of gastric acid secretion
- Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
- Onset of antisecretory effect within one hour
- Maximum effect occurring within two hours
- Inhibition of secretion lasts up to 72 hours
- Return of secretory activity over 3 to 5 days after discontinuation
Dosage
- Dosage for benign gastric and duodenal ulcer
- Dosage for NSAID-associated duodenal or gastric ulcer
- Dosage for gastro-esophageal reflux disease
- Dosage for long-term management of acid reflux disease
- Dosage for acid-related dyspepsia
- Dosage for prophylaxis of acid aspiration
- Dosage for Zollinger-Ellison syndrome
- Dosage for Helicobacter pylori eradication regimen
- Pediatric use in severe ulcerating reflux esophagitis
- Dosage for IV injection
Administration
- Direction for use of IV Injection
- Direction for use of IV Infusion
- Use of freshly prepared solution
- Reconstitution of the injection
- Intravenous administration only
Interaction
- Decreased intragastric acidity affecting absorption of ketoconazole
- Metabolism in the liver through cytochrome P450
- Potential delay in the elimination of diazepam, phenytoin, and warfarin
- Plasma concentrations during concomitant administration
- No evidence of interaction with certain substances
Contraindications
- Known hypersensitivity to omeprazole
- Exclusion of malignancy before treatment with omeprazole
- When gastric ulcer is suspected
Side Effects
- Skin rash, urticaria, and pruritus
- Photosensitivity, bullous eruption, and erythema multiforme
- Diarrhea and headache
- Gastrointestinal reactions including constipation, nausea/vomiting, flatulence, and abdominal pain
- Dizziness, light headedness, and feeling faint
- Reversible mental confusion, agitation, depression, and hallucinations
- Increases in liver enzymes
Pregnancy & Lactation
- Results from prospective epidemiological studies
- No adverse effects on pregnancy or fetus/newborn child
- Use during pregnancy
- No information available on passage into breast milk
- Discontinuation of breastfeeding if essential use is considered
Precautions & Warnings
- Avoid concomitant use of clopidogrel and omeprazole
- Potential association with increased risk for osteoporosis-related fractures
- Atrophic gastritis in patients treated long-term
Therapeutic Class
- Proton Pump Inhibitor
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children