Omenta 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 6.00 (10 x 10: ৳ 600.00)

Strip Price: ৳ 60.00

Medicine Details

Category	Details
Generic	Omeprazole
Company	Jenphar bangladesh ltd
Also available as	Omenta 40 mg injection

Indications

Gastric and duodenal ulcer
NSAID-associated duodenal and gastric ulcer
As prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
Gastro-esophageal reflux disease
Long-term management of acid reflux disease
Acid-related dyspepsia
Severe ulcerating reflux esophagitis
Prophylaxis of acid aspiration during general anesthesia
Zollinger-Ellison syndrome
Helicobacter pylori-induced peptic ulcer

Pharmacology

Inhibitor of gastric acid secretion, onset of antisecretory effect occurs within one hour, maximum effect within two hours, inhibition of secretion lasts up to 72 hours

Dosage

Benign gastric and duodenal ulcer: 20 mg once daily for 4 weeks in duodenal ulceration, 8 weeks in gastric ulceration
NSAID-associated duodenal or gastric ulcer: 20 mg once daily for 4 weeks, continued for further 4 weeks if not fully healed
Gastro-esophageal reflux disease: 20 mg once daily for 4 weeks, continued for further 4-8 weeks, if not fully healed
Long-term management of acid reflux disease: 10-20 mg daily
Acid-related dyspepsia: 10-20 mg once daily for 2-4 weeks
Prophylaxis of acid aspiration: 40 mg on the preceding evening, then 40 mg 2-6 hours before surgery
Zollinger-Ellison syndrome: Initially 60 mg once daily, usual range 20-120 mg daily
Helicobacter pylori eradication regimen in peptic ulcer disease: Omeprazole is recommended at a dose of 20 mg twice daily in association with antimicrobial agents
Paediatric use in severe ulcerating reflux esophagitis: If body-weight 10-20 kg, 10-20 mg once daily for 4-12 weeks; if body-weight over 20 kg, 20-40 mg once daily for 4-12 weeks

Administration

Direction for use of IV Injection: Omeprazole IV injection should be given as a slow intravenous injection
Direction for use of IV Infusion: Omeprazole IV infusion should be given as an intravenous infusion over a period of 20-30 minutes or more

Interaction

Absorption of ketoconazole may be reduced during Omeprazole treatment
Metabolized in the liver through cytochrome P450, can delay the elimination of diazepam, phenytoin, and warfarin
Concomitant treatment with Omeprazole and clarithromycin may increase plasma concentrations
No evidence of interaction with phenacetin, theophylline, caffeine, propranolol, metoprolol, cyclosporin, lidocaine, quinidine, estradiol, amoxicillin, or antacids

Contraindications

Omeprazole is contraindicated in patients with known hypersensitivity to it

Side Effects

Skin rash, urticaria, and pruritus
Photosensitivity, bullous eruption, erythema multiforme, angioedema, and alopecia
Diarrhoea, headache, constipation, nausea/vomiting, flatulence, and abdominal pain
Dry mouth, stomatitis, and candidiasis
Paraesthesia, dizziness, light-headedness, feeling faint, somnolence, insomnia, and vertigo
Reversible mental confusion, agitation, depression, and hallucinations
Arthritic and myalgic symptoms
Blurred vision, taste disturbance, peripheral oedema, increased sweating, gynaecomastia, leucopenia, thrombocytopenia, agranulocytosis, pancytopenia, anaphylactic shock, malaise, fever, bronchospasm, encephalopathy, hepatitis, interstitial nephritis, and hepatic failure
Increases in liver enzymes

Pregnancy & Lactation

Results from three prospective epidemiological studies indicate no adverse effects of Omeprazole on pregnancy or on the health of the fetus/newborn child. Omeprazole can be used during pregnancy

Precautions & Warnings

Avoid concomitant use of clopidogrel and Omeprazole
Observational studies suggest that PPI therapy may be associated with an increased risk for osteoporosis-related fractures
Atrophic gastritis has been noted occasionally in gastric corpus biopsies from patients treated long-term with Omeprazole
Concomitant use of PPIs with methotrexate may lead to methotrexate toxicities