Omex 40 mg/vial (IV Injection)

40 mg vial: ৳ 90.00

Medicine Details

Category	Details
Generic	Omeprazole
Company	Kemiko pharmaceuticals ltd
Also available as	Omex 20 mg capsule Omex 40 mg capsule

Indications

Gastric and duodenal ulcer
NSAID-associated duodenal and gastric ulcer
As prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
Gastro-esophageal reflux disease
Long-term management of acid reflux disease
Acid-related dyspepsia
Severe ulcerating reflux esophagitis
Prophylaxis of acid aspiration during general anesthesia
Zollinger-Ellison syndrome
Helicobacter pylori-induced peptic ulcer

Pharmacology

Inhibitor of gastric acid secretion, onset of effect within one hour, lasts up to 72 hours, metabolic pathway through cytochrome P450

Dosage

20 mg once daily for benign gastric and duodenal ulcer
40 mg daily for severe or recurrent cases
10-20 mg daily for acid-related dyspepsia
40 mg on the preceding evening for prophylaxis of acid aspiration
Recommended dose of 20 mg twice daily for Helicobacter pylori eradication regimen

Administration

IV injection for prophylaxis of acid aspiration, duodenal ulcer, gastric ulcer, or reflux oesophagitis, direction for use of IV injection and IV infusion

Interaction

Decreased intragastric acidity affects the absorption of ketoconazole
Metabolized in the liver through cytochrome P450, can delay the elimination of diazepam, phenytoin, and warfarin
Plasma concentrations of Omeprazole and clarithromycin are increased during concomitant administration
Absorption of Omeprazole is not affected by alcohol or food
No evidence of interaction with phenacetin, theophylline, caffeine, propranolol, metoprolol, cyclosporin, lidocaine, quinidine, estradiol, amoxicillin, or antacids
Simultaneous treatment with Omeprazole and digoxin leads to a 10% increase in the bioavailability of digoxin

Contraindications

Known hypersensitivity, suspicion of gastric ulcer with possibility of malignancy

Side Effects

Skin rash, urticaria, pruritus
Photosensitivity, bullous eruption, erythema multiforme, angioedema, alopecia
Diarrhoea, headache
Constipation, nausea/vomiting, flatulence, abdominal pain
Dry mouth, stomatitis, candidiasis
Paraesthesia, dizziness, light headedness, feeling faint
Somnolence, insomnia, vertigo
Reversible mental confusion, agitation, depression, hallucinations
Arthritic and myalgic symptoms
Blurred vision, taste disturbance, peripheral oedema
Increased sweating, gynaecomastia, leucopenia, thrombocytopenia, agranulocytosis, pancytopenia
Anaphylactic shock, malaise, fever, bronchospasm
Encephalopathy in patients with pre-existing severe liver disease, hepatitis with or without jaundice

Pregnancy & Lactation

No adverse effects on pregnancy or fetus/newborn child observed in prospective epidemiological studies, no information on passage into breast milk

Precautions & Warnings

Avoid concomitant use of clopidogrel
Possible association with increased risk for osteoporosis-related fractures
Atrophic gastritis noted occasionally in patients treated long-term
Concomitant use with methotrexate may lead to methotrexate toxicities

Therapeutic Class

Proton Pump Inhibitor

Storage Conditions

Keep in a dry place away from light and heat, keep out of the reach of children