Perizol 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 5.00 (100's pack: ৳ 500.00)

Medicine Details

Category Details
Generic Omeprazole
Company Leon pharmaceuticals ltd
Also available as
Perizol 40 mg capsule

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • As prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of antisecretory effect within one hour
  • Maximum effect occurring within two hours
  • Inhibition of secretion lasts up to 72 hours
  • Discontinuation leads to gradual return of secretory activity over 3 to 5 days

Dosage

  • Oral administration for specific conditions and durations
  • IV injection for prophylaxis of acid aspiration
  • IV infusion for duodenal ulcer, gastric ulcer, or reflux oesophagitis
  • Paediatric use in severe ulcerating reflux esophagitis

Administration

  • Direction for use of IV Injection
  • Direction for use of IV Infusion
  • Intravenous administration only
  • Slow intravenous injection
  • Intravenous infusion over a period of 20-30 minutes

Interaction

  • Decreased intragastric acidity affecting absorption of ketoconazole
  • Metabolism through cytochrome P450 affecting diazepam, phenytoin, and warfarin
  • Plasma concentrations of Perizol and clarithromycin are increased during concomitant administration
  • No evidence of interaction with specific drugs, alcohol, or food
  • Simultaneous treatment with digoxin leads to a 10% increase in the bioavailability of digoxin

Contraindications

  • Hypersensitivity to Omeprazole
  • Possibility of malignancy when gastric ulcer is suspected

Side Effects

  • Mild and reversible adverse reactions
  • Skin rash, urticaria, and pruritus
  • Photosensitivity, bullous eruption, and erythema multiforme
  • Diarrhoea, headache, constipation, nausea/vomiting, and abdominal pain
  • Dry mouth, stomatitis, and candidiasis
  • Dizziness, light headedness, and feeling faint
  • Mental confusion, agitation, and depression
  • Arthritic and myalgic symptoms
  • Other isolated cases of adverse reactions

Pregnancy & Lactation

  • No adverse effects on pregnancy or fetus/newborn child from prospective epidemiological studies
  • Use during pregnancy with no adverse effects indicated
  • No information available on passage into breast milk or effects on the neonate
  • Discontinuation of breastfeeding if essential use is considered

Precautions & Warnings

  • Avoid concomitant use of clopidogrel and Perizol
  • Possible increased risk for osteoporosis-related fractures with PPI therapy
  • Atrophic gastritis noted occasionally in long-term use
  • Concomitant use with methotrexate may lead to toxicities

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

Related Brands