Omemed 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 5.00 (100's pack: ৳ 500.00)

Medicine Details

Category	Details
Generic	Omeprazole
Company	Medrx life science ltd
Also available as	Omemed 40 mg capsule

Indications

Gastric and duodenal ulcer
NSAID-associated duodenal and gastric ulcer
Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
Gastro-esophageal reflux disease
Long-term management of acid reflux disease
Severe ulcerating reflux esophagitis
Prophylaxis of acid aspiration during general anesthesia
Zollinger-Ellison syndrome
Helicobacter pylori-induced peptic ulcer

Pharmacology

Omeprazole, a substituted benzimidazole, is an inhibitor of gastric acid secretion. It inhibits gastric acid secretion by blocking hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system in the gastric parietal cell.

Dosage

Benign gastric and duodenal ulcer: 20 mg once daily for 4 weeks in duodenal ulceration, 8 weeks in gastric ulceration
NSAID-associated duodenal or gastric ulcer: 20 mg once daily for 4 weeks
Gastro-esophageal reflux disease: 20 mg once daily for 4 weeks, continued for further 4-8 weeks if not fully healed
Long-term management of acid reflux disease: 10-20 mg daily
Acid-related dyspepsia: 10-20 mg once daily for 2-4 weeks
Prophylaxis of acid aspiration: 40 mg on the preceding evening, then 40 mg 2-6 hours before surgery
Zollinger-Ellison syndrome: Initially 60 mg once daily; usual range 20-120 mg daily
Helicobacter pylori eradication regimen in peptic ulcer disease: Omeprazole is recommended at a dose of 20 mg twice daily in association with antimicrobial agents
Paediatric use in severe ulcerating reflux esophagitis: 10-40 mg once daily for 4-12 weeks

Administration

Omeprazole injection should be given slowly over a period of 5 minutes. Use only freshly prepared solution.

Interaction

Due to the decreased intragastric acidity, the absorption of certain drugs may be reduced during Omeprazole treatment. Omeprazole can delay the elimination of diazepam, phenytoin, and warfarin. Plasma concentrations of Omeprazole and clarithromycin may be increased during concomitant administration, as useful interactions during H. pylori eradication

Contraindications

Omeprazole is contraindicated in patients with known hypersensitivity to it

Side Effects

Skin rash, urticaria, and pruritus
Photosensitivity, bullous eruption, erythema multiforme, angioedema, and alopecia
Diarrhoea and headache
Gastrointestinal reactions including constipation, nausea/vomiting, flatulence, and abdominal pain
Dry mouth, stomatitis, and candidiasis
Paraesthesia
Dizziness, light headedness, and feeling faint
Somnolence, insomnia, and vertigo
Reversible mental confusion, agitation, depression, and hallucinations
Arthritic and myalgic symptoms
Blurred vision, taste disturbance, peripheral oedema, increased sweating, and gynaecomastia
Leucopenia, thrombocytopenia, agranulocytosis, pancytopenia, and anaphylactic shock
Malaise, fever, bronchospasm, encephalopathy, hepatitis, interstitial nephritis, and hepatic failure
Increases in liver enzymes

Pregnancy & Lactation

Omeprazole can be used during pregnancy but breastfeeding should be discontinued if the use of Omeprazole is considered essential. Safety and effectiveness have not been established in pediatric patients less than 18 years of age

Precautions & Warnings

Avoid concomitant use of clopidogrel and Omeprazole
PPI therapy may be associated with an increased risk for osteoporosis-related fractures
Atrophic gastritis has been noted occasionally in patients treated long-term with Omeprazole
Concomitant use of PPIs with methotrexate may lead to methotrexate toxicities