Omenaaf 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 5.50 (10 x 10: ৳ 550.00)
Strip Price: ৳ 55.00

Medicine Details

Category Details
Generic Omeprazole
Company Naafco pharma ltd

Indications

  • Treatment of gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer treatment
  • Prophylaxis for patients with a history of NSAID-associated ulcers
  • Gastro-esophageal reflux disease treatment
  • Long-term management of acid reflux disease
  • Treatment of acid-related dyspepsia
  • Severe ulcerating reflux esophagitis treatment
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome treatment
  • Helicobacter pylori-induced peptic ulcer treatment

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase enzyme system
  • Onset of antisecretory effect within one hour
  • Maximum effect occurring within two hours
  • Inhibition of secretion lasts up to 72 hours
  • Gradual return of secretory activity over 3 to 5 days

Dosage

  • 20 mg once daily for benign gastric and duodenal ulcer
  • 20 mg once daily for NSAID-associated duodenal or gastric ulcer
  • 20 mg once daily for gastro-esophageal reflux disease
  • 10-20 mg daily for long-term management of acid reflux disease
  • 10-20 mg once daily for acid-related dyspepsia
  • 40 mg on the preceding evening and 2-6 hours before surgery for prophylaxis of acid aspiration
  • Initially 60 mg once daily for Zollinger-Ellison syndrome
  • 20 mg twice daily for Helicobacter pylori eradication regimen in peptic ulcer disease
  • 10-20 mg once daily for paediatric severe ulcerating reflux esophagitis
  • 40 mg IV for prophylaxis of acid aspiration
  • 40 mg IV for duodenal ulcer, gastric ulcer, or reflux oesophagitis
  • 60 mg IV for Zollinger-Ellison syndrome

Administration

  • IV injection for intravenous administration only
  • IV infusion over a period of 20-30 minutes or more
  • Use of freshly prepared solution
  • Reconstituted solution should not be mixed with other drugs

Interaction

  • Decreased intragastric acidity affecting ketoconazole absorption
  • Metabolized in the liver through cytochrome P450
  • Delay in elimination of diazepam, phenytoin, and warfarin
  • Increased plasma concentrations during concomitant administration with clarithromycin
  • No interaction with phenacetin, theophylline, caffeine, and more

Contraindications

Known hypersensitivity to omeprazole

Side Effects

  • Mild and reversible adverse reactions
  • Skin rash, urticaria, and pruritus
  • Diarrhoea, headache, constipation, nausea/vomiting
  • Dizziness, somnolence, insomnia, vertigo
  • Arthritic and myalgic symptoms
  • Liver enzyme increases

Pregnancy & Lactation

No adverse effects of omeprazole on pregnancy or on the health of the fetus/newborn child

Precautions & Warnings

  • Avoid concomitant use of clopidogrel
  • Increased risk for osteoporosis-related fractures
  • Atrophic gastritis noted in patients treated long-term
  • Concomitant use with methotrexate may lead to toxicities

Therapeutic Class

Proton Pump Inhibitor

Storage Conditions

Keep in a dry place away from light and heat

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