Orpra 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 5.00

Medicine Details

Category Details
Generic Omeprazole
Company Orbit pharmaceuticals ltd
Also available as
Orpra 40 mg capsule

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase enzyme system
  • Onset of antisecretory effect within one hour
  • Maximum effect within two hours
  • Inhibition of secretion lasts up to 72 hours
  • Gradual return of secretory activity over 3 to 5 days upon discontinuation

Dosage

  • Different dosage for different indications
  • Oral and IV administration options
  • Dose adjustment for severe or recurrent cases

Administration

  • IV injection directions
  • IV infusion directions
  • Reconstitution and usage instructions

Interaction

  • Potential interactions with ketoconazole, diazepam, phenytoin, warfarin, clarithromycin, metronidazole, amoxicillin, piroxicam, diclofenac, naproxen, alcohol, food, and more

Contraindications

  • Known hypersensitivity to omeprazole
  • Suspicion of malignancy in gastric ulcer cases

Side Effects

  • Mild and reversible adverse reactions
  • Skin rash, urticaria, pruritus
  • Photosensitivity, bullous eruption, erythema multiforme
  • Diarrhoea, headache, constipation, nausea/vomiting
  • Dry mouth, stomatitis, candidiasis
  • Dizziness, somnolence, insomnia, vertigo
  • Reversible mental confusion, agitation, depression, hallucinations
  • Arthritic and myalgic symptoms
  • Blurred vision, taste disturbance, peripheral edema
  • Leucopenia, thrombocytopenia, agranulocytosis, pancytopenia
  • Malaise, fever, bronchospasm, hepatitis, hepatic failure

Pregnancy & Lactation

  • No adverse effects on pregnancy or fetus/child health based on studies
  • Use during pregnancy is considered safe
  • No information on passage into breast milk or effects on neonate
  • Discontinuation of breastfeeding if essential

Precautions & Warnings

  • Avoid concomitant use with clopidogrel
  • Potential association with increased risk for osteoporosis-related fractures
  • Atrophic gastritis noted in long-term use
  • Potential methotrexate toxicities with concomitant use

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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