Ranzo 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 4.00 (60's pack: ৳ 240.00)

Medicine Details

Category Details
Generic Omeprazole
Company Oyster pharmaceuticals ltd

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of antisecretory effect occurs within one hour
  • Maximum effect occurs within two hours
  • Inhibition of secretion lasts up to 72 hours
  • Secretory activity returns gradually over 3 to 5 days after drug discontinuation

Dosage

  • Specific dosage for various indications such as gastric and duodenal ulcer, NSAID-associated duodenal or gastric ulcer, gastro-esophageal reflux disease, long-term management of acid reflux disease, acid-related dyspepsia, prophylaxis of acid aspiration, Zollinger-Ellison syndrome, Helicobacter pylori eradication regimen, and pediatric use
  • Oral dosage and IV injection dosage guidelines

Administration

  • Direction for use of IV Injection
  • Direction for use of IV Infusion
  • Instructions for intravenous administration
  • Reconstitution guidelines for IV injection and IV infusion
  • Stability considerations for reconstituted solution
  • Intravenous administration details

Interaction

  • Information about drug interactions with other medications
  • Metabolism through cytochrome P450
  • Effects on absorption of ketoconazole, diazepam, phenytoin, warfarin, clarithromycin, and digoxin
  • Absence of interaction with certain medications like phenacetin, theophylline, caffeine, propranolol, and others

Contraindications

  • Known hypersensitivity to omeprazole
  • Caution when gastric ulcer is suspected to exclude malignancy before treatment

Side Effects

  • Adverse reactions such as skin rash, urticaria, pruritus, photosensitivity, bullous eruption, erythema multiforme, diarrhea
  • Headache, constipation, nausea/vomiting, flatulence, abdominal pain, dry mouth, stomatitis, candidiasis
  • Paraesthesia, dizziness, light headedness, feeling faint, somnolence, insomnia, vertigo, mental confusion
  • Agitation, depression, hallucinations, arthritic and myalgic symptoms, blurred vision, taste disturbance, and others
  • Increase in liver enzymes

Pregnancy & Lactation

  • Results from prospective epidemiological studies
  • Use during pregnancy
  • Recommendation to discontinue breastfeeding if essential use of omeprazole is considered

Precautions & Warnings

  • Avoid concomitant use of clopidogrel and omeprazole
  • Potential association of PPI therapy with increased risk for osteoporosis-related fractures
  • Atrophic gastritis in patients treated long-term with omeprazole
  • Potential methotrexate toxicities with PPIs

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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