Presectil 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 4.00 (100's pack: ৳ 400.00)

Medicine Details

Category Details
Generic Omeprazole
Company Premier pharmaceuticals ltd

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of the antisecretory effect within one hour
  • Maximum effect occurring within two hours
  • Inhibition of secretion lasts up to 72 hours
  • Gradual return of secretory activity over 3 to 5 days after discontinuation

Dosage

  • 20 mg once daily for benign gastric and duodenal ulcer
  • 8 weeks of 20 mg once daily for gastric ulceration
  • Increased dose to 40 mg daily for severe or recurrent cases
  • Maintenance dose for recurrent duodenal ulcer is 20 mg once daily
  • Recommended dosage for NSAID-associated duodenal or gastric ulcer
  • Dose escalation for gastro-esophageal reflux disease
  • 10-20 mg daily for long-term management of acid reflux disease
  • Omeprazole dose for prophylaxis of acid aspiration
  • Initial and usual range of doses for Zollinger-Ellison syndrome
  • Recommended dose for Helicobacter pylori eradication regimen
  • Specified dosages for pediatric use in severe ulcerating reflux esophagitis
  • Specific dosages for IV injection in various conditions

Administration

  • Omeprazole IV injection for intravenous administration only
  • Omeprazole IV injection should be given as a slow intravenous injection
  • Omeprazole IV infusion for intravenous infusion over a period of 20-30 minutes or more
  • Preparation and usage instructions for IV injection
  • Preparation and usage instructions for IV infusion
  • Stability and usage duration after reconstitution

Interaction

  • Impact on the absorption of ketoconazole and other drugs
  • Metabolism through cytochrome P450 affecting the elimination of certain drugs
  • Specific interactions with clarithromycin, phenytoin, warfarin, and other drugs
  • Effects on the bioavailability and plasma concentrations of certain drugs

Contraindications

  • Known hypersensitivity to omeprazole
  • Exclusion of malignancy before treatment initiation in suspected gastric ulcer

Side Effects

  • Mild and reversible adverse reactions
  • Skin reactions including rash, urticaria, and pruritus
  • Photosensitivity, bullous eruption, erythema multiforme, and angioedema
  • Diarrhoea, headache, constipation, nausea/vomiting, flatulence, and abdominal pain
  • Other gastrointestinal reactions including dry mouth, stomatitis, and candidiasis
  • Neurological symptoms like paraesthesia, dizziness, and somnolence
  • Reversible mental confusion, agitation, and depression
  • Arthritic and myalgic symptoms
  • Possible liver and blood-related adverse effects
  • Impact on liver enzymes

Pregnancy & Lactation

  • Results from prospective epidemiological studies
  • No adverse effects on pregnancy or fetal/newborn health
  • Recommendation for use during pregnancy
  • Lack of information on passage into breast milk and effects on the neonate
  • Discontinuation recommendation during breastfeeding
  • Lack of established safety and effectiveness in pediatric patients

Precautions & Warnings

  • Avoid concomitant use of clopidogrel and omeprazole
  • Association with increased risk for osteoporosis-related fractures
  • Potential for atrophic gastritis with long-term use
  • Concerns with concomitant use with methotrexate

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Dry place away from light and heat
  • Keep out of reach of children

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