Pear 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 4.50

Medicine Details

Category Details
Generic Omeprazole
Company Prime pharmaceuticals ltd

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • As prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of antisecretory effect occurs within one hour
  • Maximum effect within two hours
  • Inhibition of secretion lasts up to 72 hours

Dosage

  • 20 mg once daily for benign gastric and duodenal ulcer
  • 8 weeks in gastric ulceration
  • 40 mg daily for severe or recurrent cases
  • Maintenance dose for recurrent duodenal ulcer - 20 mg once daily
  • 10-20 mg daily for long-term acid reflux disease management
  • 10-20 mg once daily for acid-related dyspepsia
  • 40 mg on the preceding evening for prophylaxis of acid aspiration
  • Initial dose of 60 mg once daily for Zollinger-Ellison syndrome
  • 20 mg twice daily for Helicobacter pylori eradication regimen in peptic ulcer disease
  • 10-20 mg once daily for severe ulcerating reflux esophagitis (pediatric use)

Administration

  • Intravenous administration only
  • Slow intravenous injection
  • Intravenous infusion over a period of 20-30 minutes
  • Reconstituted solution should be used within 4 hours of reconstitution

Interaction

  • Decreased intragastric acidity affecting ketoconazole absorption
  • Metabolised in the liver through cytochrome P450
  • Can delay the elimination of diazepam, phenytoin, and warfarin
  • Plasma concentrations are increased during concomitant administration

Contraindications

  • Known hypersensitivity to Omeprazole
  • Exclusion of malignancy before treatment with omeprazole

Side Effects

  • Skin rash, urticaria, and pruritus
  • Photosensitivity, bullous eruption, and erythema multiforme
  • Diarrhea and headache
  • Gastrointestinal reactions including constipation and nausea/vomiting
  • Dry mouth, stomatitis, and candidiasis
  • Dizziness, lightheadedness, and feeling faint
  • Reversible mental confusion, agitation, and depression
  • Arthritic and myalgic symptoms
  • Increases in liver enzymes

Pregnancy & Lactation

  • No adverse effects on pregnancy or fetus/newborn child
  • Can be used during pregnancy
  • No information available on passage into breast milk or effects on the neonate

Precautions & Warnings

  • Avoid concomitant use of clopidogrel and Omeprazole
  • Proton pump inhibitor (PPI) therapy may be associated with an increased risk for osteoporosis-related fractures
  • Atrophic gastritis noted in patients treated long-term with Omeprazole
  • Concomitant use of PPIs with methotrexate may lead to methotrexate toxicities

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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