Omilux 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 5.00 (100's pack: ৳ 500.00)

Medicine Details

Category Details
Generic Omeprazole
Company Quality pharmaceuticals ltd

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • As prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of antisecretory effect within one hour
  • Maximum effect occurring within two hours
  • Inhibition of secretion lasts up to 72 hours
  • Gradual return of secretory activity over 3 to 5 days post discontinuation

Dosage

  • 20 mg once daily for benign gastric and duodenal ulcer
  • 20 mg once daily for NSAID-associated duodenal or gastric ulcer
  • 20 mg once daily for gastro-esophageal reflux disease
  • 10-20 mg daily for long-term management of acid reflux disease
  • 10-20 mg once daily for acid-related dyspepsia
  • 40 mg on the preceding evening, then 40 mg 2-6 hours before surgery for prophylaxis of acid aspiration

Administration

  • For intravenous administration only
  • Slow intravenous injection required
  • Intravenous infusion over a period of 20-30 minutes
  • Reconstituted solution should be used within specified time
  • Cannot be mixed or co-administered with other drugs in the same infusion set

Interaction

  • Decreased intragastric acidity affecting the absorption of ketoconazole
  • Metabolized in the liver through cytochrome P450
  • Potential delay in elimination of diazepam, phenytoin, and warfarin
  • Monitoring recommended for patients receiving warfarin or phenytoin
  • Plasma concentrations increased during concomitant administration with certain drugs
  • No evidence of interaction with specific medications

Contraindications

  • Known hypersensitivity to omeprazole
  • Suspicion of gastric ulcer without excluding malignancy

Side Effects

  • Mild and reversible adverse reactions
  • Skin rash, urticaria, and pruritus reported
  • Photosensitivity, bullous eruption, and erythema multiforme in isolated cases
  • Diarrhea and headache, which may be severe enough to require discontinuation of therapy
  • Other gastrointestinal reactions such as constipation, nausea/vomiting, and abdominal pain
  • Dizziness, light headedness, and feeling faint reported

Pregnancy & Lactation

  • No adverse effects on pregnancy or fetal health reported
  • Safe for use during pregnancy
  • No information available on passage into breast milk or effects on the neonate
  • Breastfeeding should be discontinued if essential

Precautions & Warnings

  • Avoid concomitant use with clopidogrel
  • Potential association with increased risk for osteoporosis-related fractures
  • Atrophic gastritis noted occasionally with long-term use
  • Concomitant use with methotrexate may lead to methotrexate toxicities

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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