Presec 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 7.00 (7 x 4: ৳ 196.00)
Strip Price: ৳ 28.00

Medicine Details

Category Details
Generic Omeprazole
Company Unimed unihealth pharmaceuticals ltd
Also available as
Presec 20 mg capsule

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • As prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

Inhibitor of gastric acid secretion; blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system in the gastric parietal cell; onset of antisecretory effect occurs within one hour, with maximum effect within two hours; inhibition of secretion lasts up to 72 hours; gradually returns to normal after discontinuation over 3 to 5 days

Dosage

  • Oral dosage for different conditions
  • IV Injection dosage for prophylaxis of acid aspiration, duodenal ulcer, gastric ulcer, reflux esophagitis, Zollinger-Ellison syndrome

Administration

  • IV Injection: Intravenous administration only; should be given as a slow intravenous injection; solution should be used within 4 hours of reconstitution
  • IV Infusion: Intravenous infusion over a period of 20-30 minutes or more; reconstituted solution should not be mixed with any other drug

Interaction

May affect the absorption and elimination of other medications; monitoring recommended with concurrent warfarin or phenytoin treatment; increased plasma concentrations during coadministration with certain medications

Contraindications

Contraindicated in patients with known hypersensitivity; possibility of malignancy should be excluded before treatment

Side Effects

  • Mild and reversible adverse reactions reported; skin rash, urticaria, pruritus, photosensitivity, bullous eruption, erythema multiforme, angioedema, alopecia, diarrhea, headache, constipation, nausea/vomiting, flatulence, dry mouth, stomatitis, candidiasis, paraesthesia, dizziness, mental confusion, depression, arthritic and myalgic symptoms, blurred vision, taste disturbance, peripheral edema, increased sweating, and more

Pregnancy & Lactation

No adverse effects on pregnancy or fetus reported in studies; use during pregnancy is acceptable; effects on breast milk and newborn unknown

Precautions & Warnings

  • Avoid concomitant use with clopidogrel
  • May be associated with increased risk for osteoporosis-related fractures
  • Atrophic gastritis noted in long-term treatment
  • Concomitant use with methotrexate may lead to toxicities

Therapeutic Class

Proton Pump Inhibitor

Storage Conditions

Keep in a dry place away from light and heat; keep out of the reach of children

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