Prazover 20 mg (Capsule (Enteric Coated))
Unit Price: ৳ 5.01 (10 x 10: ৳ 501.00)
Strip Price: ৳ 50.10
Medicine Details
Category | Details |
---|---|
Generic | Omeprazole |
Company | Veritas pharmaceuticals ltd |
Also available as |
Indications
- Gastric and duodenal ulcer
- NSAID-associated duodenal and gastric ulcer
- Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
- Gastro-esophageal reflux disease
- Long-term management of acid reflux disease
- Acid-related dyspepsia
- Severe ulcerating reflux esophagitis
- Prophylaxis of acid aspiration during general anesthesia
- Zollinger-Ellison syndrome
- Helicobacter pylori-induced peptic ulcer
Pharmacology
- Inhibitor of gastric acid secretion
- Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
- Onset of antisecretory effect within one hour
- Maximum effect within two hours
- Inhibition of secretion lasts up to 72 hours
- Gradual return of secretory activity over 3 to 5 days after discontinuation
Dosage
- Oral administration
- Benign gastric and duodenal ulcer: 20 mg once daily for 4-8 weeks
- NSAID-associated duodenal or gastric ulcer: 20 mg once daily for 4 weeks, maintenance dose for prevention of relapse in duodenal ulcer: 10-20 mg daily
- Gastro-esophageal reflux disease: 20 mg once daily for 4-8 weeks, maintenance dose 20 mg once daily
- Long-term management of acid reflux disease: 10-20 mg daily
- Prophylaxis of acid aspiration: 40 mg on the preceding evening, then 40 mg 2-6 hours before surgery
- Zollinger-Ellison syndrome: Initially 60 mg once daily, usual range 20-120 mg daily
- Helicobacter pylori eradication regimen in peptic ulcer disease: Omeprazole is recommended at a dose of 20 mg twice daily in association with antimicrobial agents for one week
- Pediatric use in severe ulcerating reflux esophagitis: 10-20 mg once daily for 4-12 weeks (if body-weight 10-20 kg) and 20-40 mg once daily for 4-12 weeks (if body-weight over 20 kg)
- IV Injection: Prophylaxis of acid aspiration: Omeprazole 40 mg to be given slowly as an intravenous injection, one hour before surgery
Administration
- IV Injection - for intravenous administration only
- IV Infusion - intravenous infusion over a period of 20-30 minutes or more
- Use of freshly prepared solution
- Solution for IV injection should be given slowly over a period of at least 2 to 5 minutes at a maximum rate of 4 ml/minute
Interaction
- Decreased intragastric acidity affecting the absorption of ketoconazole
- Metabolism through cytochrome P450 delaying the elimination of diazepam, phenytoin, and warfarin
- Increase in plasma concentrations of Omeprazole and clarithromycin during concomitant administration
- No evidence of interaction with phenacetin, theophylline, caffeine, propranolol, metoprolol, cyclosporin, lidocaine, quinidine, estradiol, amoxicillin, antacids, piroxicam, diclofenac, or naproxen
- Increase in the bioavailability of digoxin during simultaneous treatment with Omeprazole
Contraindications
- Known hypersensitivity to Omeprazole
- Suspicion of malignancy when gastric ulcer is suspected
Side Effects
- Mild and reversible adverse reactions
- Skin rash, urticaria, pruritus, photosensitivity, bullous eruption, erythema multiforme
- Diarrhea, headache, constipation, nausea/vomiting, flatulence, abdominal pain
- Dry mouth, stomatitis, candidiasis, paraesthesia
- Dizziness, light headedness, feeling faint, somnolence, insomnia, vertigo
- Reversible mental confusion, agitation, depression, hallucinations
- Arthritic and myalgic symptoms, blurred vision, taste disturbance, peripheral edema, increased sweating, gynaecomastia, leucopenia, thrombocytopenia, agranulocytosis, pancytopenia, anaphylactic shock, malaise, fever, bronchospasm, encephalopathy, hepatitis, interstitial nephritis, hepatic failure
- Increase in liver enzymes
Pregnancy & Lactation
- No adverse effects of Omeprazole on pregnancy or on the health of the fetus/newborn child
- Use during pregnancy permitted, no information available on passage into breast milk or effects on the neonate
- Discontinuation of breast-feeding if essential use of Omeprazole
Precautions & Warnings
- Avoid concomitant use of clopidogrel and Prazover
- Possible increased risk for osteoporosis-related fractures with PPI therapy
- Atrophic gastritis noted occasionally with long-term use
- Concomitant use of PPIs with methotrexate may lead to methotrexate toxicities
Therapeutic Class
- Proton Pump Inhibitor
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children
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