Prazover 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 5.01 (10 x 10: ৳ 501.00)
Strip Price: ৳ 50.10

Medicine Details

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of antisecretory effect within one hour
  • Maximum effect within two hours
  • Inhibition of secretion lasts up to 72 hours
  • Gradual return of secretory activity over 3 to 5 days after discontinuation

Dosage

  • Oral administration
  • Benign gastric and duodenal ulcer: 20 mg once daily for 4-8 weeks
  • NSAID-associated duodenal or gastric ulcer: 20 mg once daily for 4 weeks, maintenance dose for prevention of relapse in duodenal ulcer: 10-20 mg daily
  • Gastro-esophageal reflux disease: 20 mg once daily for 4-8 weeks, maintenance dose 20 mg once daily
  • Long-term management of acid reflux disease: 10-20 mg daily
  • Prophylaxis of acid aspiration: 40 mg on the preceding evening, then 40 mg 2-6 hours before surgery
  • Zollinger-Ellison syndrome: Initially 60 mg once daily, usual range 20-120 mg daily
  • Helicobacter pylori eradication regimen in peptic ulcer disease: Omeprazole is recommended at a dose of 20 mg twice daily in association with antimicrobial agents for one week
  • Pediatric use in severe ulcerating reflux esophagitis: 10-20 mg once daily for 4-12 weeks (if body-weight 10-20 kg) and 20-40 mg once daily for 4-12 weeks (if body-weight over 20 kg)
  • IV Injection: Prophylaxis of acid aspiration: Omeprazole 40 mg to be given slowly as an intravenous injection, one hour before surgery

Administration

  • IV Injection - for intravenous administration only
  • IV Infusion - intravenous infusion over a period of 20-30 minutes or more
  • Use of freshly prepared solution
  • Solution for IV injection should be given slowly over a period of at least 2 to 5 minutes at a maximum rate of 4 ml/minute

Interaction

  • Decreased intragastric acidity affecting the absorption of ketoconazole
  • Metabolism through cytochrome P450 delaying the elimination of diazepam, phenytoin, and warfarin
  • Increase in plasma concentrations of Omeprazole and clarithromycin during concomitant administration
  • No evidence of interaction with phenacetin, theophylline, caffeine, propranolol, metoprolol, cyclosporin, lidocaine, quinidine, estradiol, amoxicillin, antacids, piroxicam, diclofenac, or naproxen
  • Increase in the bioavailability of digoxin during simultaneous treatment with Omeprazole

Contraindications

  • Known hypersensitivity to Omeprazole
  • Suspicion of malignancy when gastric ulcer is suspected

Side Effects

  • Mild and reversible adverse reactions
  • Skin rash, urticaria, pruritus, photosensitivity, bullous eruption, erythema multiforme
  • Diarrhea, headache, constipation, nausea/vomiting, flatulence, abdominal pain
  • Dry mouth, stomatitis, candidiasis, paraesthesia
  • Dizziness, light headedness, feeling faint, somnolence, insomnia, vertigo
  • Reversible mental confusion, agitation, depression, hallucinations
  • Arthritic and myalgic symptoms, blurred vision, taste disturbance, peripheral edema, increased sweating, gynaecomastia, leucopenia, thrombocytopenia, agranulocytosis, pancytopenia, anaphylactic shock, malaise, fever, bronchospasm, encephalopathy, hepatitis, interstitial nephritis, hepatic failure
  • Increase in liver enzymes

Pregnancy & Lactation

  • No adverse effects of Omeprazole on pregnancy or on the health of the fetus/newborn child
  • Use during pregnancy permitted, no information available on passage into breast milk or effects on the neonate
  • Discontinuation of breast-feeding if essential use of Omeprazole

Precautions & Warnings

  • Avoid concomitant use of clopidogrel and Prazover
  • Possible increased risk for osteoporosis-related fractures with PPI therapy
  • Atrophic gastritis noted occasionally with long-term use
  • Concomitant use of PPIs with methotrexate may lead to methotrexate toxicities

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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