Opezen 20 mg (Tablet (Enteric Coated))

Unit Price: ৳ 4.00 (10 x 10: ৳ 400.00)
Strip Price: ৳ 40.00

Medicine Details

Category Details
Generic Omeprazole
Company Zenith pharmaceuticals ltd
Also available as
Opezen 40 mg tablet

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Severe ulcerating reflux esophagitis
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer
  • Long-term management of acid reflux disease
  • Prophylaxis of acid aspiration during general anesthesia
  • Acid-related dyspepsia

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocker of hydrogen-potassium-adenosine triphosphatase enzyme system
  • Onset of antisecretory effect within one hour
  • Maximum effect occurring within two hours
  • Inhibition of secretion lasting up to 72 hours
  • Gradual return of secretory activity over 3 to 5 days after discontinuation

Dosage

  • Oral administration
  • Benign gastric and duodenal ulcer dosage
  • NSAID-associated duodenal or gastric ulcer dosage
  • Gastro-esophageal reflux disease dosage
  • Long-term management of acid reflux disease dosage
  • Acid-related dyspepsia dosage
  • Prophylaxis of acid aspiration dosage
  • Zollinger-Ellison syndrome dosage
  • Paediatric use dosage
  • IV injection dosage

Administration

  • Intravenous administration
  • Direction for use of IV Injection
  • Direction for use of IV Infusion
  • Reconstitution of injection
  • Intravenous infusion over 20-30 minutes or more
  • Dissolution in saline for infusion or 5% Dextrose for infusion
  • Solution usage time limits

Interaction

  • Effects on absorption of ketoconazole
  • Metabolism through cytochrome P450
  • Interaction with diazepam, phenytoin, and warfarin
  • Concomitant treatment effects on phenytoin and warfarin
  • Plasma concentration increase during concomitant administration
  • No evidence of interaction with specific drugs

Contraindications

  • Known hypersensitivity
  • Exclusion of malignancy before treatment

Side Effects

  • Skin rash, urticaria, pruritus
  • Photosensitivity, bullous eruption, erythema multiforme
  • Diarrhoea, headache
  • Constipation, nausea/vomiting, flatulence, abdominal pain
  • Dry mouth, stomatitis, candidiasis
  • Paraesthesia, dizziness, light headedness
  • Mental confusion, agitation, depression, hallucinations
  • Arthritic and myalgic symptoms
  • Other reported cases

Pregnancy & Lactation

  • No adverse effects on pregnancy or fetus health
  • Use during pregnancy
  • Unknown passage into breast milk
  • Discontinuation of breastfeeding if essential use
  • Safety and effectiveness not established in pediatric patients

Precautions & Warnings

  • Avoid concomitant use of clopidogrel
  • Potential risk for osteoporosis-related fractures
  • Atrophic gastritis with long-term use
  • Concomitant use with methotrexate may lead to toxicities

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Dry place away from light and heat
  • Keep out of the reach of children

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