Periset 8 mg/4 ml (IM/IV Injection)
4 ml ampoule: ৳ 30.10 (1 x 5: ৳ 150.50)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ondansetron |
| Company | Acme laboratories ltd |
| Also available as |
Indications
- Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy
- Prevention and treatment of post-operative nausea and vomiting
- Prevention of radiotherapy-induced nausea and vomiting
Description
- Orally dissolving film designed to be applied on top of the tongue
- Dissolves within 20 seconds
- Does not require water to aid dissolution or swallowing
- Active ingredient: Periset base
Pharmacology
- Potent, highly selective 5HT3 receptor-antagonist
- Precise mode of action not fully known
- Blocks initiation of vomiting reflex
- May promote emesis through a central mechanism
Dosage
- Adult dosage for chemotherapy-induced nausea and vomiting
- Pediatric dosage for chemotherapy-induced nausea and vomiting
- Dosage for radiotherapy-induced nausea and vomiting
- Dosage for postoperative nausea and vomiting
- Oral solution dosage for radiotherapy induced nausea and vomiting
- Dosing instructions for oral soluble film
Administration
- Step by step administration guide for oral soluble film
Interaction
- Does not induce or inhibit the cytochrome P-450 drug-metabolizing enzyme system
- Metabolized by hepatic cytochrome P-450 drug-metabolizing enzymes
Contraindications
- Hypersensitivity to the drug or any of its components
- Concomitant use of apomorphine
Side Effects
- Frequently reported adverse events
- Mild or moderate adverse events
- Rare cases of serious adverse events
- Adverse events specific to chemotherapy-induced nausea and vomiting
- No evidence of extrapyramidal reactions
Pregnancy & Lactation
- Carcinogenic effects not seen in animal studies
- No evidence of impaired fertility or harm to fetus
- Excretion in breast milk
- Caution advised during nursing
Precautions & Warnings
- Hypersensitivity reactions reported
- Not a drug that stimulates gastric or intestinal peristalsis
- Caution advised in patients following abdominal surgery
- Caution advised in patients with chemotherapy-induced nausea and vomiting
Use in Special Populations
- Dosage adjustment for patients with impaired renal function
- Dosage adjustment for patients with impaired hepatic function
- Little information available for pediatric patients 4 years of age or younger
- No dosage adjustment needed in patients over the age of 65
Therapeutic Class
- Anti-emetic drugs
Storage Conditions
- Store at temperature not exceeding 30°C
- Store in a dry place
- Protect from light and moisture