Periset 8 mg (Tablet)
Unit Price: ৳ 10.03 (3 x 10: ৳ 300.90)
Strip Price: ৳ 100.30
Medicine Details
| Category | Details |
|---|---|
| Generic | Ondansetron |
| Company | Acme laboratories ltd |
| Also available as |
Indications
- Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy
- Prevention and treatment of post-operative nausea and vomiting
- Prevention of radiotherapy-induced nausea and vomiting
Category
Anti-emetic drugs
Formulation
Oral soluble film
Active Ingredient
Periset base (Ondansetron)
Chemical Formula
C18H19N3O
Dosage Forms
- Tablet
- Orodispersible tablet
- Injection
- Oral solution
Dosage Guidance
- Dose based on body weight
- Specific dosages for different age groups
- Dosage adjustments for different chemotherapy and radiotherapy regimens
Mechanism of Action
Selective blocking agent of the serotonin 5-HT3 receptor type
Mode of Administration
Oral administration
Administration Instructions
- Oral soluble film designed to be applied on top of the tongue
- Dissolves within 20 seconds
- No water required for dissolution
- Instructions for swallowing after dissolution
Interactions
Metabolized by hepatic cytochrome P-450 drug-metabolizing enzymes
Contraindications
- Hypersensitivity to the drug or any of its components
- Concomitant use of apomorphine
Common Side Effects
- Headache
- Constipation
- Diarrhea
- Rash
- Sensation of flushing or warmth
- Hiccups
Rare Side Effects
- Anaphylaxis
- Brochospasm
- Tachycardia
- Angina
- Hypokalemia
- Shortness of breath
Pregnancy & Lactation
- No evidence of harm in animal studies
- Caution advised during nursing
Precautions
- Caution in patients with hypersensitivity to other selective 5-HT3 receptor antagonists
- Not a stimulant of gastric or intestinal peristalsis
- Not a replacement for nasogastric suction
- May mask a progressive ileus and/or gastric distension
Hepatic Impairment Dosage Adjustment
Single maximal daily dose of 8 mg recommended
Pediatric Usage
Limited information available for patients 4 years of age or younger
Storage Conditions
Store at temperature not exceeding 30°C in a dry place, protect from light and moisture