Seroset 8 mg (Tablet)
Unit Price: ৳ 7.00 (30's pack: ৳ 210.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ondansetron |
| Company | Globex pharmaceuticals ltd |
| Also available as |
Indications
- Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy
- Prevention and treatment of post-operative nausea and vomiting
- Prevention of radiotherapy-induced nausea and vomiting
Dosage
- Dosage varies for different conditions such as Chemotherapy-Induced Nausea and Vomiting, Radiotherapy-Induced Nausea and Vomiting, and Postoperative Nausea and Vomiting
- Available in 4mg orodispersible tablet, 8mg tablet/orodispersible tablet, and injection formulations
- Dosage adjustments for highly emetogenic cancer chemotherapy and moderately emetogenic cancer chemotherapy based on age and weight
Administration
- Oral soluble film designed to dissolve in the mouth within 20 seconds and then be swallowed with saliva
- Does not require water for dissolution and swallowing
- Simple steps for administration include tearing the pouch, placing the film on the tongue, and swallowing after dissolution
Interaction
- Metabolized by hepatic cytochrome P-450 drug-metabolizing enzymes, potential for interactions with enzyme inhibitors or inducers
- No dosage adjustment recommended based on available data
Contraindications
- Contraindicated in patients with hypersensitivity to the drug or any of its components
- Concomitant use of apomorphine
Side Effects
- Common side effects include headache, constipation, and diarrhea
- Other reported adverse events include rash, flushing, hiccups, liver enzyme abnormalities, anaphylaxis, bronchospasm, tachycardia, angina, hypokalemia, and shortness of breath
- No evidence of extrapyramidal reactions
Pregnancy & Lactation
- No evidence of carcinogenic effects in animal studies
- Not mutagenic in standard tests for mutagenicity
- Caution advised when administered to nursing women due to excretion in breast milk
Precautions & Warnings
- Hypersensitivity reactions reported in patients with hypersensitivity to other selective 5-HT3 receptor antagonists
- Not a stimulant of gastric or intestinal peristalsis
- Caution needed in patients following abdominal surgery or with chemotherapy-induced nausea and vomiting to avoid masking progressive ileus or gastric distension
Use in Special Populations
- Dosage adjustment is not needed for patients with impaired renal function
- Severe hepatic impairment may require a dosage adjustment
- Limited information available for dosage in pediatric patients 4 years of age or younger
Therapeutic Class
- Anti-emetic drugs
Storage Conditions
- Store at a temperature not exceeding 30°C in a dry place
- Protect from light and moisture
Pharmacology
- Ondansetron is a potent, highly selective 5HT3 receptor-antagonist
- Mechanism of action includes antagonism of 5HT3 receptors in both peripheral and central nervous systems
Description
- Oral soluble film designed to dissolve within 20 seconds and then be swallowed with saliva
- Active ingredient is Ondansetron, a selective blocking agent of the serotonin 5-HT3 receptor type
- Empirical formula is C18H19N3O, representing a molecular weight of 293.3
Drug Classes
- Belongs to the therapeutic class of anti-emetic drugs