Nauset 8 mg/4 ml (IM/IV Injection)

4 ml ampoule: ৳ 30.00 (1 x 5: ৳ 150.00)

Medicine Details

Category Details
Generic Ondansetron
Company Navana pharmaceuticals ltd
Also available as
Nauset 4 mg oral solution Nauset 8 mg tablet

Product Title and Category

  • Nauset - Anti-emetic drugs

Indications

  • Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy
  • Prevention and treatment of post-operative nausea and vomiting
  • Prevention of radiotherapy-induced nausea and vomiting

Type of Product

  • Oral soluble film

Active Ingredient

  • Nauset base (the racemic form of Nauset)
  • Selective blocking agent of the serotonin 5-HT3 receptor type

Chemical Formula and Molecular Weight

  • C18H19N3O
  • Molecular weight of 293.3

Mode of Action

  • Potent, highly selective 5HT3 receptor-antagonist
  • Blocks initiation of reflex causing nausea and vomiting
  • Antagonism of 5HT3 receptors in peripheral and central nervous system

Dosage Forms

  • Oral dissolving film
  • 8 mg orodispersible tablet
  • 4 mg orodispersible tablet
  • Injection
  • Oral solution

Dosage Instructions

  • Different doses for adults, pediatric patients, and radiotherapy
  • Dosage adjustments for patients with impaired renal or hepatic function

Administration Instructions

  • Oral film dissolves within 20 seconds on the tongue
  • No water required for swallowing

Interaction with Drug-metabolizing Enzymes

  • Metabolized by hepatic cytochrome P-450 drug-metabolizing enzymes
  • Inducers or inhibitors of these enzymes may change clearance and half-life

Contraindications

  • Hypersensitivity to the drug or any of its components
  • Concomitant use of apomorphine

Common Side Effects

  • Headache
  • Constipation
  • Diarrhea
  • Rash
  • Sensation of flushing or warmth
  • Hiccups
  • Liver enzyme abnormalities

Rare Side Effects

  • Anaphylaxis
  • Bronchospasm
  • Tachycardia
  • Angina
  • Hypokalemia
  • Shortness of breath
  • Extrapyramidal reactions

Pregnancy and Lactation

  • No evidence of carcinogenic effects in animal studies
  • No mutagenicity in standard tests
  • Caution advised during breastfeeding

Precautions and Warnings

  • Reported hypersensitivity reactions in patients
  • Not a stimulant for gastric or intestinal peristalsis

Special Populations

  • No dosage adjustment needed for patients with impaired renal function
  • Special dosage recommendation for patients with severe hepatic impairment

Therapeutic Class

  • Anti-emetic drugs

Storage Conditions

  • Store at temperatures not exceeding 30°C
  • Protect from light and moisture

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