Pukenil 4 mg/5 ml (Oral Solution)
50 ml bottle: ৳ 44.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ondansetron |
| Company | Team pharmaceuticals ltd |
| Also available as |
Title and Categories
- Pukenil Oral Soluble Film
- Anti-emetic drugs
Indications
- Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy
- Prevention and treatment of post-operative nausea and vomiting
- Prevention of radiotherapy-induced nausea and vomiting
Formulation
Orally dissolving film
Application Method
- Applied on top of the tongue
- Dissolves within 20 seconds
- Swallowed with saliva
Active Ingredient
Pukenil base
Chemical Formula
C18H19N3O
Molecular Weight
293.3
Pharmacological Action
5HT3 receptor-antagonist
Mode of Action
- Blocks activation of vagal afferents
- Antagonizes 5HT3 receptors in the peripheral and central nervous system
Dosage Forms
- 8 mg tablet/orodispersible tablet
- 4 mg orodispersible tablet
- Injection
- Oral solution
Dosage and Administration
- Doses based on patient age and emetogenicity of chemotherapy or radiotherapy
- Different dosages for adults and pediatric patients
Administration Instructions
- Tear the pouch along the edge tear mark
- Place film on top of the tongue
- Do not chew or swallow the film whole
- Swallow after the film dissolves
Interaction with Cytochrome P-450 System
Metabolized by hepatic cytochrome P-450 drug-metabolizing enzymes
Contraindications
- Hypersensitivity to the drug or any of its components
- Concomitant use of apomorphine
Side Effects
- Headache
- Constipation
- Diarrhea
- Rash
- Sensation of flushing or warmth
- Hiccups
- Liver enzyme abnormalities
- Anaphylaxis
- Bronchospasm
- Tachycardia
- Angina
- Hypokalemia
- Shortness of breath
Pregnancy and Lactation
- Carcinogenic effects not seen in animal studies
- Not mutagenic in standard tests
- Excreted in breast milk of rats
- Caution in nursing women
Precautions and Warnings
- Hypersensitivity reactions reported in patients with hypersensitivity to other selective 5-HT3 receptor antagonists
- Should not be used instead of nasogastric suction
- May mask a progressive ileus and/or gastric distension
Special Population Considerations
- Dosage adjustment for renal function
- Dosage adjustment for severe hepatic impairment
- Limited information for pediatric patients 4 years of age or younger
- No dosage adjustment needed in patients over the age of 65
Therapeutic Class
Anti-emetic drugs
Storage Conditions
Store at temperature not exceeding 30°C in a dry place. Protect from light and moisture