Emeset 8 mg (Tablet)
Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ondansetron |
| Company | Veritas pharmaceuticals ltd |
| Also available as |
Title and Categories
- Emeset Oral Soluble Film
- Anti-emetic drugs
Indications
- Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy
- Prevention and treatment of post-operative nausea and vomiting
- Prevention of radiotherapy-induced nausea and vomiting
Dosage Instructions
- 8 mg tablet/orodispersible tablet
- 4 mg orodispersible tablet
- Injection
- Oral Solution
- Highly emetogenic cancer chemotherapy dosage
- Moderate emetogenic cancer chemotherapy dosage
- Pediatric dosage
- Adult dosage
- Total body irradiation dosage
- Single high-dose fraction radiotherapy to the abdomen dosage
- Daily fractionated radiotherapy to the abdomen dosage
Product Description
- Orally dissolving film
- Designed to be applied on top of the tongue
- Dissolves within 20 seconds
- Swallowed with saliva
- Contains Emeset base, a selective blocking agent of the serotonin 5-HT3 receptor type
- Empirical formula: C18H19N3O
- Molecular weight: 293.3
Pharmacology
- Potent, highly selective 5HT3 receptor-antagonist
- Precise mode of action not fully known
- Blocks initiation of vomiting reflex
- Blocks 5HT3 receptors in peripheral and central nervous system
Mode of Administration
- Tear the pouch carefully along with the edge tear mark
- Place the film on top of the tongue
- Do not chew or swallow the film whole
- Swallow after the film dissolves
- Wash hands after taking the film
Interaction Information
- Metabolized by hepatic cytochrome P-450 drug-metabolizing enzymes
- Inducers or inhibitors of these enzymes may change clearance and half-life of Emeset
Contraindications
- Hypersensitivity to the drug or any of its components
- Concomitant use of apomorphine
Side Effects
- Frequently reported adverse events: headache, constipation, diarrhea
- Mild or moderate in nature
- Rash, sensation of flushing or warmth, hiccups, liver enzyme abnormalities reported
- Rare cases of anaphylaxis, bronchospasm, tachycardia, chest pain, hypokalemia, shortness of breath reported
Pregnancy & Lactation
- Carcinogenic effects not seen in 2-year studies in rats and mice
- Not mutagenic in standard tests
- No evidence of impaired fertility or harm to the fetus in animal studies
- Caution advised when administered to nursing women
Precautions & Warnings
- Hypersensitivity reactions reported in patients with hypersensitivity to other 5-HT3 receptor antagonists
- Not a drug that stimulates gastric or intestinal peristalsis
- Should not be used instead of nasogastric suction
- May mask progressive ileus and/or gastric distension
Use in Special Populations
- Dosage adjustment for patients with impaired renal function
- Dosage adjustment for patients with impaired hepatic function
- Little information available about dosage in pediatric patients 4 years of age or younger
- No dosage adjustment needed in patients over the age of 65
Therapeutic Class
- Anti-emetic drugs
Storage Conditions
- Store at temperature not exceeding 30°C
- Store in a dry place
- Protect from light and moisture