Emeset 4 mg/5 ml (Oral Solution)
50 ml bottle: ৳ 45.14
Medicine Details
| Category | Details |
|---|---|
| Generic | Ondansetron |
| Company | Veritas pharmaceuticals ltd |
| Also available as |
Indications
- Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy
- Prevention and treatment of post-operative nausea and vomiting
- Prevention of radiotherapy-induced nausea and vomiting
Type
Oral Soluble Film
Design
Orally dissolving film designed to be applied on top of the tongue where it will dissolve within 20 seconds
Active Ingredient
Emeset base
Molecular Weight
293.3
Mechanism of Action
Selective blocking agent of the serotonin 5-HT3 receptor type
Dosage
- 8 mg tablet/orodispersible tablet
- 4 mg orodispersible tablet
- Injection
Dosage Adjustments
Severe hepatic impairment may require a single maximal daily dose of 8 mg
Administration
- Tear the pouch carefully along the edge tear mark
- Put the film on top of your tongue and allow it to dissolve
- Do not chew or swallow the film whole
- Swallow after the film dissolves
Drug Interactions
Metabolized by hepatic cytochrome P-450 drug-metabolizing enzymes, and may have its clearance and half-life affected by inducers or inhibitors of these enzymes
Contraindications
- Hypersensitivity to the drug or any of its components
- Concomitant use of apomorphine
Side Effects
- Headache
- Constipation
- Diarrhea
- Rash
- Sensation of flushing or warmth
- Hiccups
- Liver enzyme abnormalities
Adverse Reactions
- Anaphylaxis
- Bronchospasm
- Tachycardia
- Angina
- Hypokalemia
- Shortness of breath
Carcinogenic Effects
Not seen in 2-year studies in rats and mice with oral Ondansetron doses
Mutagenicity
Not mutagenic in standard tests
Pregnancy & Lactation
- No evidence of impaired fertility or harm to the fetus due to Ondansetron in animal studies
- Caution advised when administered to nursing women
Precautions
- Hypersensitivity reactions reported in patients with hypersensitivity to other selective 5-HT3 receptor antagonists
- Should not be used instead of nasogastric suction
- May mask a progressive ileus and/or gastric distension
Special Populations
- Dosage recommendation same for patients with impaired renal function
- Patients with severe hepatic impairment recommended a single maximal daily dose of 8 mg
Therapeutic Class
Anti-emetic drugs
Storage Conditions
Store at temperature not exceeding 30°C in a dry place, protect from light and moisture