Oxiplat 5 mg/ml (IV Infusion)
50 mg vial: ৳ 2,500.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Oxaliplatin |
| Company | Drug international ltd |
Indications
- Adjuvant treatment of stage III colon cancer in patients who have undergone complete resection of the primary tumor
- Treatment of advanced colorectal cancer
Pharmacology
- Undergoes nonenzymatic conversion in physiologic solutions
- Forms transient reactive species that covalently bind with macromolecules
- Forms Pt-DNA crosslinks inhibiting DNA replication and transcription
- Cell-cycle nonspecific cytotoxicity
Dosage & Administration
- Administer every 2 weeks
- For advanced disease, treatment is recommended until disease progression or unacceptable toxicity
- For adjuvant use, treatment is recommended for a total of 6 months (12 cycles)
- Specific dosages for Day 1 and Day 2 administration
Interaction
- No specific cytochrome P-450-based drug interaction studies conducted
- Increases of 5-fluorouracil plasma concentrations by approximately 20% with certain dosages
- Platinum-containing species elimination primarily through the kidney
Contraindications
- Contraindicated in patients with known allergy to oxaliplatin or other platinum compounds
Side Effects
- Peripheral sensory neuropathy
- Neutropenia
- Thrombocytopenia
- Nausea
- Increase in transaminases and alkaline phosphatase
- Diarrhea
- Emesis
- Fatigue
- Stomatitis
- Other reported adverse reactions
Pregnancy & Lactation
- Pregnancy Category D
- May cause fetal harm
- No adequate and well-controlled studies in pregnant women
- Advice for women of childbearing potential
- Excretion in human milk unknown
- Consideration for discontinuing nursing
Precautions & Warnings
- Grade 3/4 hypersensitivity observed in colon cancer patients
- Neurological toxicity monitoring and examination
- Neuropathy management and prevention
- Pulmonary toxicity associated with oxaliplatin
- Hepatotoxicity and related reactions
- Cardiovascular toxicity and recommended ECG monitoring
Overdose Effects
- No known antidote
- Thrombocytopenia
- Hypersensitivity reaction
- Myelosuppression
- Nausea
- Vomiting
- Diarrhea
- Neurotoxicity
Therapeutic Class
- Cytotoxic Chemotherapy
Storage Conditions
- Store in a cool & dry place
- Protected from light and moisture
- Keep out of reach of children