Oxaliplat 5 mg/ml (IV Infusion)
50 mg vial: ৳ 2,998.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Oxaliplatin |
| Company | Healthcare pharmaceuticals ltd |
Title
- Oxaliplat (Oxaliplatin)
Categories
- Anti-cancer Medication
- Chemotherapy Drug
- Cytotoxic Treatment
Description
- Oxaliplat is used in combination with infusional 5-fluorouracil/folinic acid for the adjuvant treatment of stage III colon cancer and the treatment of advanced colorectal cancer.
Indications
- Adjuvant treatment of stage III colon cancer after complete resection
- Treatment of advanced colorectal cancer
Pharmacology
- Undergoes nonenzymatic conversion to active derivatives
- Forms Pt-DNA crosslinks inhibiting DNA replication and transcription
- Shows antitumor activity against colon carcinoma
DosageAndAdministration
- Administered every 2 weeks in combination with 5-fluorouracil/folinic acid
- Recommended treatment duration for advanced disease and adjuvant use
- Specific dosage regimen for Day 1 and Day 2 administrations
Interaction
- No specific cytochrome P-450-based drug interactions observed
- Possible increase in 5-fluorouracil plasma concentrations with higher Oxaliplat doses
- Clearance may be decreased by coadministration of potentially nephrotoxic compounds
Contraindications
- Contraindicated in patients with known allergy to oxaliplatin or other platinum compounds
SideEffects
- Common adverse reactions include peripheral sensory neuropathy, neutropenia, thrombocytopenia, nausea, and more
- Serious adverse reactions reported
PregnancyAndLactation
- Pregnancy Category D
- May cause fetal harm
- No adequate and well-controlled studies in pregnant women
- Decision for nursing mothers should consider the importance of the drug to the mother
PrecautionsAndWarnings
- Grade 3/4 hypersensitivity reactions observed in 2-3% of patients
- Neurological toxicity monitoring required
- Pulmonary, hepatotoxicity, and cardiovascular toxicity warnings
OverdoseEffects
- No known antidote
- Complications of overdose include hypersensitivity reaction, myelosuppression, nausea, vomiting, and neurotoxicity
- Reported cases of overdoses and observed adverse reactions
TherapeuticClass
- Cytotoxic Chemotherapy
StorageConditions
- Store in a cool & dry place
- Protected from light and moisture
- Keep out of reach of children