Patron 0.075 mg/1.5 ml (IV Injection)

1.5 ml ampoule: ৳ 75.00

Medicine Details

Category	Details
Generic	Palonosetron
Company	Acme laboratories ltd
Also available as	Patron 025 mg injection Patron 05 mg tablet

Indications

Acute and delayed nausea and vomiting
Uncontrolled nausea and vomiting
Chemotherapy-induced nausea and vomiting
Radiotherapy-induced nausea and vomiting
Post-operative & Post-discharge nausea and vomiting

Pharmacology

5-HT3 receptor antagonist
Binding affinity for 5-HT3 receptor
Inhibition of serotonin actions
Metabolism and excretion
Linear dose-proportional pharmacokinetics
Volume of distribution
Plasma protein binding
Metabolism via kidney and liver
Excretion in urine
Total body clearance
Half-life
Greater 5-HT3 receptor binding affinity

Dosage & Administration

Usual dosage for adults
Dosage for chemotherapy-induced nausea and vomiting
Dosage for radiotherapy-induced nausea and vomiting
Dosage for post-operative nausea and vomiting
Dosage for children
Administration via tablet
Administration via IV
Administration timing

Interaction

Safety with corticosteroids
Safety with analgesics
Safety with antiemetics/antinauseants
Safety with antispasmodics
Safety with anticholinergic agents
No inhibition of antitumor activity
No significant pharmacokinetic interactions
No inhibition of specific CYP enzymes
Low potential for drug interactions

Contraindications

Hypersensitivity to the drug or its components

Side Effects

Headaches
Constipation

Pregnancy & Lactation

Pregnancy category 'B'
Excretion in breast milk

Use in Special Populations

No dosage adjustment in elderly patients
Dosage for children
No dosage adjustment in patients with renal and hepatic dysfunction

Overdose Effects

No known antidote
Supportive care management

Therapeutic Class

Anti-emetic drugs

Storage Conditions

Cool and dry storage
Protection from light

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