Patron 0.075 mg/1.5 ml (IV Injection)
1.5 ml ampoule: ৳ 75.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Palonosetron |
| Company | Acme laboratories ltd |
| Also available as |
Indications
- Acute and delayed nausea and vomiting
- Uncontrolled nausea and vomiting
- Chemotherapy-induced nausea and vomiting
- Radiotherapy-induced nausea and vomiting
- Post-operative & Post-discharge nausea and vomiting
Pharmacology
- 5-HT3 receptor antagonist
- Binding affinity for 5-HT3 receptor
- Inhibition of serotonin actions
- Metabolism and excretion
- Linear dose-proportional pharmacokinetics
- Volume of distribution
- Plasma protein binding
- Metabolism via kidney and liver
- Excretion in urine
- Total body clearance
- Half-life
- Greater 5-HT3 receptor binding affinity
Dosage & Administration
- Usual dosage for adults
- Dosage for chemotherapy-induced nausea and vomiting
- Dosage for radiotherapy-induced nausea and vomiting
- Dosage for post-operative nausea and vomiting
- Dosage for children
- Administration via tablet
- Administration via IV
- Administration timing
Interaction
- Safety with corticosteroids
- Safety with analgesics
- Safety with antiemetics/antinauseants
- Safety with antispasmodics
- Safety with anticholinergic agents
- No inhibition of antitumor activity
- No significant pharmacokinetic interactions
- No inhibition of specific CYP enzymes
- Low potential for drug interactions
Contraindications
- Hypersensitivity to the drug or its components
Side Effects
- Headaches
- Constipation
Pregnancy & Lactation
- Pregnancy category 'B'
- Excretion in breast milk
Use in Special Populations
- No dosage adjustment in elderly patients
- Dosage for children
- No dosage adjustment in patients with renal and hepatic dysfunction
Overdose Effects
- No known antidote
- Supportive care management
Therapeutic Class
- Anti-emetic drugs
Storage Conditions
- Cool and dry storage
- Protection from light