Palostat 0.075 mg/1.5 ml (IV Injection)
1.5 ml ampoule: ৳ 75.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Palonosetron |
| Company | Ibn sina pharmaceuticals ltd |
| Also available as |
Indications
- Acute and delayed nausea and vomiting
- Uncontrolled nausea and vomiting
- Chemotherapy-induced nausea and vomiting (CINV)
- Radiotherapy-induced nausea and vomiting (RINV)
- Post-operative & Post-discharge nausea and vomiting (PONV & PDNV)
Pharmacology
- 5-HT3 receptor antagonist
- Strong binding affinity for 5-HT3 receptor
- Little or no affinity for other receptors
- Inhibition of serotonin actions
- Binding affinity to 5-HT3 receptor
- Linear dose-proportional pharmacokinetics
- Metabolism via kidney and liver
- Longer half-life
- Greater 5-HT3 receptor binding affinity
Dosage & Administration
- Adult tablet dosage: 0.5 mg daily
- Adult IV dosage: 0.075 mg over 10 seconds
- Administered prior to chemotherapy or radiotherapy
- Children dosage: 20 mcg/kg body weight, maximum 1.5 mg
Interaction
- Safe administration with corticosteroids, analgesics, antiemetics, antinauseants, antispasmodics, and anticholinergic agents
- No significant pharmacokinetic interactions with metoclopramide
- Low potential for clinically significant drug interactions
Contraindications
- Hypersensitivity to the drug or any of its components
Side Effects
- Headaches
- Constipation
Pregnancy & Lactation
- Pregnancy category 'B'
- Unknown excretion in breast milk
Use in Special Populations
- No dosage adjustment recommended for elderly patients
- Specific dosage for children
- No dosage adjustment recommended for patients with renal and hepatic dysfunction
Overdose Effects
- No known antidote
- Supportive care management
Therapeutic Class
- Anti-emetic drugs
Storage Conditions
- Cool & dry place
- Protected from light