Palostat 0.25 mg/5 ml (IV Injection)
5 ml ampoule: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Palonosetron |
| Company | Ibn sina pharmaceuticals ltd |
| Also available as |
Indications
- Acute and delayed nausea and vomiting
- Uncontrolled nausea and vomiting
- Chemotherapy-induced nausea and vomiting (CINV)
- Radiotherapy-induced nausea and vomiting (RINV)
- Post-operative & Post-discharge nausea and vomiting (PONV & PDNV)
Pharmacology
- 5-HT3 receptor antagonist
- Strong binding affinity for 5-HT3 receptor
- Little or no affinity for other receptors
- Influence on postoperative nausea and vomiting
- Selective participation in the emetic response
- Works by blocking the actions of serotonin at 5-HT3 receptor
- Linear dose-proportional pharmacokinetics
- Volume of distribution of approximately 6.9-7.9 L/kg
- Metabolized via kidney and liver CYP isoenzymes
- Excreted as unchanged drug in the urine
Dosage & Administration
- Usual dosage for adults and children
- Different dosage for chemotherapy-induced, radiotherapy-induced, and post-operative nausea and vomiting
- Administration route for tablet and IV dosage
Interaction
- Safety with corticosteroids, analgesics, and antiemetics/antinauseants
- No inhibition of antitumor activity of specific chemotherapeutic agents
- No significant pharmacokinetic interactions with metoclopramide
- Low potential for clinically significant drug interactions
Contraindications
- Hypersensitivity to the drug or any of its components
Side Effects
- Headaches
- Constipation
Pregnancy & Lactation
- Pregnancy category 'B'
- Unknown excretion in breast milk
Use in Special Populations
- No dosage adjustment in elderly patients >65 years of age
- Specific dosage for children and elderly patients
- No dosage adjustment for patients with impaired renal and hepatic function
Overdose Effects
- No known antidote
- Management with supportive care
Therapeutic Class
- Anti-emetic drugs
Storage Conditions
- Cool & dry place
- Protected from light