Pantotop 40 mg (Tablet (Enteric Coated))

Unit Price: ৳ 8.00 (7 x 10: ৳ 560.00)
Strip Price: ৳ 80.00

Medicine Details

Category Details
Generic Pantoprazole sodium
Company Benham pharmaceuticals ltd
Also available as
Pantotop 20 mg tablet

Indications

  • Peptic ulcer diseases
  • Gastroesophageal reflux diseases
  • Ulcer induced by non-steroidal anti-inflammatory drugs (NSAIDs)
  • Eradication of Helicobacter pylori (in combination with antibiotics)
  • Zollinger-Ellison Syndrome

Pharmacology

Proton pump inhibitor that suppresses the final step in gastric acid production by covalently binding to the H+/K+ATPase enzyme system at the surface of the gastric parietal cell.

Dosage & Administration

  • Benign gastric ulcer: 40 mg daily in the morning for 4 weeks, continued for further 4 weeks, if not fully healed.
  • Gastro-esophageal reflux disease: 20-40 mg daily in the morning for 4 weeks, continued for further 4 weeks, if not fully healed; maintenance dose is 20 mg daily, which may be increased to 40 mg daily.
  • Duodenal ulcer: 40 mg daily in the morning for 2 weeks, continued for further 2 weeks if not fully healed.
  • Duodenal ulcer associated with Helicobacter pylori: Pantoprazole is recommended at a dose of 40 mg twice daily in association with antimicrobial agents as detailed below: Amoxycillin 1 g and Clarithromycin 500 mg both twice daily for one week, or Clarithromycin 250 mg and Metronidazole 400 mg both twice daily for one week.
  • Prophylaxis of NSAID-associated gastric or duodenal ulcer: 20 mg daily for those require long-term NSAID treatment.
  • Zollinger-Ellison Syndrome: Initially 80 mg once daily adjusted according to response (elderly max. 40 mg daily); daily doses above 80 mg given in 2 divided doses.

Interaction

No significant drug interactions have been observed in clinical studies.

Contraindications

Pantoprazole is contraindicated in patients with known hypersensitivity to any of the components of the formulation.

Side Effects

  • Headache
  • Diarrhea
  • Abdominal pain
  • Flatulence
  • Rash
  • Insomnia
  • Hyperglycemia

Pregnancy & Lactation

US FDA Pregnancy Category of Pantoprazole is B. There are, however, no adequate and well-controlled studies in pregnant woman. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Pantoprazole has been shown to be excreted in human milk. So, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the benefit of the drug to the mother.

Precautions & Warnings

Pantotop tablet should not be split, chewed or crushed. Long-term therapy of Pantotop may lead to malabsorption of cyanocobalamin (Vitamin B12) or may increase the risk of osteoporosis related disorders.

Overdose Effects

No known symptoms of overdosage in humans. Since Pantotop is highly protein bound, it is not readily dialyzable. Apart from symptomatic and supportive management, no specific therapy is recommended.

Therapeutic Class

Proton Pump Inhibitor

Reconstitution

Pantotop lyophilized powder and 0.9% Sodium Chloride Injection is for intravenous administration only and must not be given by any other route. Pantotop IV injection should be given as a slow intravenous injection.

Storage Conditions

Keep in a dry place, away from light and heat. Keep out of the reach of children.

Chemical Structure

  • Molecular Formula: C16H15F2N3O4S
  • Chemical Structure: Image of Chemical Structure of Pantoprazole Sodium

Common Questions

  • What is Pantotop 40 mg Tablet?
  • How long do I need to use Pantotop 40 mg Tablet before I see improvement in my condition?
  • At what frequency do I need to use Pantotop 40 mg Tablet?
  • Should I use Pantotop 40 mg Tablet empty stomach, before food or after food?
  • What are the instructions for the storage and disposal of Pantotop 40 mg Tablet?
  • What are the effects of Pantotop 40 mg Tablet in older adults?
  • How long does it take for Pantotop 40 mg Tablet to work?
  • Is Pantotop 40 mg Tablet safe?
  • Does Pantotop 40 mg Tablet cause weight gain?
  • What are the side effects of Pantotop 40 mg Tablet?
  • Can I take Pantotop 40 mg Tablet if I am pregnant or breastfeeding?
  • What should I do if I miss a dose of Pantotop 40 mg Tablet?

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