Toza 100 mg/5 ml (Powder for Suspension)
30 ml bottle: ৳ 35.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Nitazoxanide |
| Company | Eskayef pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of diarrhea caused by Cryptosporidium parvum
- Treatment of diarrhea caused by Giardia lamblia
- Treatment of diarrhea caused by Entamoeba histolytica
Pharmacology
- Nitazoxanide is a synthetic antiprotozoal agent for oral administration
- Interferes with the Pyruvate Ferredoxin Oxido Reductase (PFOR) enzyme-dependant electron transfer reaction
- Essential for anaerobic energy metabolism of the protozoa
Dosage & Administration
- Age 1-3 years: 1 tea-spoonfull or 5 ml suspension every 12 hours for 3 days
- Age 4-11 years: 2 tea-spoonfulls or 10 ml suspension every 12 hours for 3 days
- Age 12 years or above: 5 tea-spoonfulls (25 ml) suspension or 1 tablet every 12 hours for 3 days
- Recommended to be administered with food
Interaction
- Highly bound to plasma protein
- Caution should be exercised when administering Toza concurrently with other highly plasma protein-bound drugs with narrow therapeutic index
Contraindications
- Contraindicated in patients with known hypersensitivity to Nitazoxanide or any components of the preparation
Side Effects
- Abdominal pain
- Vomiting
- Headache
- Nausea
- Anorexia
- Flatulence
- Increased appetite
- Enlarged salivary glands
- Increased creatinine & SGPT level
- Pruritus
- Rhinitis
- Sweating
- Dizziness
- Discolored urine
Pregnancy & Lactation
- US FDA pregnancy category of Nitazoxanide is B
- No adequate and well-controlled studies in pregnant women
- Should be used during pregnancy only if clearly needed
- Nitazoxanide have been shown to be excreted in human milk
- Caution should be exercised when Nitazoxanide is administered during lactation
Precautions & Warnings
- Must be administered with caution to patients with hepatic & biliary disease
- Must be administered with caution to patients with renal disease
Therapeutic Class
- Anti-diarrhoeal
- Antiprotozoal
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children