Xanide 500 mg (Tablet)

Indications

• Treatment of diarrhea caused by Cryptosporidium parvum, Giardia lamblia, and Entamoeba histolytica

Pharmacology

• Synthetic antiprotozoal agent for oral administration
• Interference with Pyruvate Ferredoxin Oxido Reductase (PFOR) enzyme-dependant electron transfer reaction
• Active in inhibiting the growth of sporozoites and oocyst of Cryptosporidium parvum and trophozoites of Giardia lamblia

Dosage & Administration

• Age-specific dosages for 1-3 years, 4-11 years, and 12 years or above
• Recommended to be administered with food

Interaction

• Highly bound to plasma protein
• Caution when administering concurrently with other highly plasma protein-bound drugs with narrow therapeutic index

Contraindications

• Patients with known hypersensitivity to Nitazoxanide or any components of the preparation

Side Effects

• Frequent side effects of abdominal pain, vomiting, and headache
• Mild and transient nature of side effects
• Very rare side effects including nausea, anorexia, flatulence, increased appetite, enlarged salivary glands, increased creatinine & SGPT level, pruritus, rhinitis, sweating, dizziness, discolored urine

Pregnancy & Lactation

• US FDA pregnancy category B
• No adequate and well-controlled studies in pregnant women
• Caution in use during pregnancy if clearly needed
• Excreted in human milk, caution during lactation

Precautions & Warnings

• Caution in patients with hepatic & biliary disease
• Caution in patients with renal disease

Therapeutic Class

• Anti-diarrhoeal Antiprotozoal

Storage Conditions

• Keep in a dry place away from light and heat
• Keep out of the reach of children

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