Pegin 135 mcg/0.5 ml (SC Injection)

0.5 ml pre-filled syringe: ৳ 8,800.00

Medicine Details

Category Details
Generic Peginterferon alfa 2a pegylated interferon alfa 2a
Company Beacon pharmaceuticals plc
Also available as
Pegin 180 mcg injection

Indications

  • Chronic Hepatitis C
  • Chronic Hepatitis B

Pharmacology

Peginterferon alfa-2a are interferon proteins bound to polyethylene glycol (PEG) molecules resulting in higher and more prolonged serum interferon concentrations.

Dosage & Administration

  • Chronic hepatitis C: 180 mcg once weekly for 48 weeks by subcutaneous administration on abdomen or thigh
  • Chronic hepatitis B: 180 mcg once weekly for 48 weeks by subcutaneous administration on abdomen or thigh
  • Hepatitis C Genotype 1 & 4:
    • Pegylated Interferon alfa-2a Monotherapy: 180 mcg once weekly for 48 weeks
    • Pegylated Interferon alfa-2a dual therapy: 180 mcg once weekly for 48 weeks
  • Hepatitis C Genotype 2 & 3:
    • Pegylated Interferon alfa-2a Monotherapy: 180 mcg once weekly for 48 weeks
    • Pegylated Interferon alfa-2a dual therapy: 180 mcg once weekly for 24 weeks

Interaction

  • Drugs metabolized by CYP1A2
  • Methadone
  • Nucleoside analogues
  • Zidovudine
  • Azathioprine

Contraindications

  • Hypersensitivity to any component of the product
  • Autoimmune hepatitis
  • Hepatic decompensation in cirrhotic patients
  • Neonate or infants

Side Effects

  • Depression
  • Flu like symptoms
  • Gastrointestinal symptoms
  • Musculoskeletal issues
  • Neurological effects
  • Psychiatric reactions
  • Skin problems
  • Endocrine effects

Pregnancy & Lactation

Category C: Peginterferon alfa-2a monotherapy. Category X: It is not known whether peginterferon or ribavirin or its components are excreted in human milk.

Precautions & Warnings

  • Patients who have failed alpha interferon treatment with or without ribavirin
  • Liver or other organ transplant recipients
  • Hepatitis B patients coinfected with HCV or HIV

Use in Special Populations

  • Hepatic Impairment:
    • Dose modifications
    • Administer in the abdomen or thigh
  • Renal Impairment: Use caution; monitor for toxicity

Overdose Effects

There are limited experiences of overdose. There were no serious reactions attributed to overdose. There is no specific antidote.

Therapeutic Class

  • Hepatic viral infections (Hepatitis B)
  • Hepatic viral infections (Hepatitis C)

Storage Conditions

Store in refrigerator at 2-8°C; do not freeze or shake. Protect from light.

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