Pegferon 180 mcg/0.5 ml (SC Injection)

0.5 ml pre-filled syringe: ৳ 15,000.00

Medicine Details

Product Title and Categories

  • Chronic Hepatitis C and B drug

Indications

  • Treatment of adults with chronic hepatitis C virus infection
  • Treatment of adult patients with chronic hepatitis B

Pharmacology

  • Interferon proteins bound to polyethylene glycol (PEG) molecules
  • Antiviral, antiproliferative, and immune-regulating activity

Dosage and Administration

  • Recommended dose of 180 mcg once weekly for 48 weeks
  • Subcutaneous administration on abdomen or thigh

Interaction

  • Drugs metabolized by CYP1A2 monitoring
  • Methadone toxicity monitoring
  • Nucleoside analogues monitoring
  • Zidovudine monitoring
  • Azathioprine caution

Contraindications

  • Hypersensitivity to any component of the product
  • Autoimmune hepatitis
  • Hepatic decompensation in cirrhotic patients
  • Neonate or infants

Side Effects

  • Depression and suicide
  • Flu like symptoms
  • Gastrointestinal effects
  • Metabolic and Nutritional effects
  • Musculoskeletal effects
  • Neurological effects
  • Psychiatric reactions
  • Injection site reaction and skin problems
  • Endocrine effects

Pregnancy and Lactation

  • Category C for peginterferon alfa-2a monotherapy
  • Category X for peginterferon and ribavirin combination in nursing mothers

Precautions and Warnings

  • Patients who have failed alpha interferon treatment
  • Liver or other organ transplant recipients
  • Hepatitis B patients coinfected with HCV or HIV
  • Hepatitis C patients coinfected with HBV or HIV

Use in Special Populations

  • Dose modifications for adverse reactions
  • Use caution in patients with hepatic or renal impairment

Overdose Effects

  • Limited experiences of overdose
  • No serious reactions attributed to overdose
  • No specific antidote
  • Dialysis ineffective

Therapeutic Class

  • Hepatic viral infections (Hepatitis B)
  • Hepatic viral infections (Hepatitis C)

Storage Conditions

  • Store in refrigerator at 2-8° C
  • Protect from light

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