Zox 100 mg/5 ml (Powder for Suspension)

30 ml bottle: ৳ 40.00

Medicine Details

Category Details
Generic Nitazoxanide
Company Square pharmaceuticals plc
Also available as
Zox 500 mg tablet

Indications

  • Diarrhea caused by Cryptosporidium parvum
  • Diarrhea caused by Giardia lamblia
  • Diarrhea caused by Entamoeba histolytica

Pharmacology

  • Nitazoxanide is a synthetic antiprotozoal agent for oral administration
  • Interference with the Pyruvate Ferredoxin Oxido Reductase (PFOR) enzyme-dependant electron transfer reaction
  • Inhibiting the growth of sporozoites and oocyst of Cryptosporidium parvum
  • Inhibiting the growth of trophozoites of Giardia lamblia

Dosage & Administration

  • 1-3 years: 1 tea-spoonfull or 5 ml suspension every 12 hours for 3 days
  • 4-11 years: 2 tea-spoonfulls or 10 ml suspension every 12 hours for 3 days
  • 12 years or above: 5 tea-spoonfulls (25 ml) suspension or 1 tablet every 12 hours for 3 days
  • Recommended to be administered with food

Interaction

  • Highly bound to plasma protein
  • Caution with other highly plasma protein-bound drugs with narrow therapeutic index

Contraindications

  • Known hypersensitivity to Nitazoxanide or any components of the preparation

Side Effects

  • Abdominal pain
  • Vomiting
  • Headache
  • Nausea
  • Anorexia
  • Flatulence
  • Increased appetite
  • Enlarged salivary glands
  • Increased creatinine & SGPT level
  • Pruritus
  • Rhinitis
  • Sweating
  • Dizziness
  • Discolored urine

Pregnancy & Lactation

  • US FDA pregnancy category B
  • No adequate and well-controlled studies in pregnant women
  • Caution during pregnancy if clearly needed
  • Excreted in human milk
  • Caution during lactation

Precautions & Warnings

  • Caution in patients with hepatic & biliary disease
  • Caution in patients with renal disease

Therapeutic Class

  • Anti-diarrhoeal
  • Antiprotozoal

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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