Thiotab 15 mg (Tablet)

Indications

• Treatment of acute cyanide poisoning
• Sequential use with sodium nitrite
• Life-threatening situations
• Use with caution if diagnosis uncertain

Pharmacology

• Acts as an antidote in cyanide poisoning
• Sulphur-donating substrate for enzyme rhodanese
• Conversion of cyanide to thiocyanide
• Speeds up detoxification process

Dosage & Administration

• Adult dosage: 12.5g of sodium thiosulfate
• Child dosage: 400 mg/kg of sodium thiosulfate
• Administration after sodium nitrite
• Repeat doses if symptoms recur

Interaction

• No formal drug interaction studies conducted

Side Effects

• Osmotic disturbances
• Catharsis (at high doses)

Pregnancy & Lactation

• Pregnancy Category C
• Use only if potential benefit justifies potential risk
• Unknown excretion in human milk
• Caution in breastfeeding
• No data on safe breastfeeding after administration

Precautions & Warnings

• May contain trace impurities of sodium sulfite
• Should not deter administration for emergency situations
• Not a contraindication for sulfite-sensitive patients

Use in Special Populations

• Limited clinical studies in pediatric population
• Caution in pediatric use
• Greater risk in patients with impaired renal function
• Monitoring renal function in geriatric use

Overdose Effects

• Reductions in oxygen saturation with high oral doses
• Recover to baseline after discontinuation

Therapeutic Class

• Antidote preparations

Storage Conditions

• Store at controlled room temperature
• Temperature range: 20°C to 25°C
• Protection from direct light
• Avoid freezing

Related Brands

• Thiotab 7.5 mg (Tablet) - sonear-laboratories-ltd