Avolac 3.35 gm/5 ml (Oral Solution)
Medicine Details
| Category | Details |
|---|---|
| Generic | Lactulose |
| Company | Aristopharma ltd |
Title
Avolac 3.35 gm/5 ml Oral Solution
Categories
- Medicine
- Laxative
- Osmotic Purgatives
Description
Avolac is a hyperosmolar laxative which is used as an effective treatment approach for constipation. It is a non-absorbable disaccharide which draws water into the bowel; causes distention through fluid accumulation, thus promotes soft stool and accelerates bowel motion.
Indications
- Constipation
- Intestinal flora disturbances
- Increased blood ammonia levels
Pharmacology
Lactulose is a synthetic disaccharide. Lactulose is metabolized in the colon by the saccharolytic bacteria, producing low molecular weight organic acids (mainly lactic acid), which lowers the pH of the colon contents, promote the retention of water by an osmotic effect; thus increasing peristaltic activity. Lactulose is minimally absorbed; therefore, the pharmacokinetics of the absorbed material are not relevant to the principal therapeutic action.
DosageAndAdministration
- Constipation:
- Adults: 3-6 tea-spoons daily initially, 1½-6 tea-spoons daily in long-term therapy
- Children up to 14 years: 3 tea-spoons daily initially, 1-2 tea-spoons daily in long-term therapy
- Infants and toddlers: 1-2 tea-spoons daily initially, 1 tea-spoon daily in long-term therapy
- DamagedIntestinalFlora:
- Adults: 1-2 tea-spoons daily
- Children: 1 tea-spoon daily
- BloodAmmoniaLevelReduction:
- Hyper-ammoniemia in hepatopathy: a maximum of 18-30 tea-spoons daily
- In portal systemic encephalopathy: hourly doses of 6-9 tea-spoons may be used to induce rapid laxation, then the dose may be reduced
Interaction
There is no significant drug interactions with Avolac. The glycosidic effect of cardiac glycosides can be intensified by potassium deficiency in abuse.
Contraindications
- Hypersensitivity to galactose and lactose
- Galactose-free diet
- Gastro-cardial symptom complex
- Suspected intestinal obstruction
SideEffects
- Flatulence
- Abdominal discomfort
- Diarrhea
- Loss of electrolytes (primarily potassium) in abuse
PregnancyAndLactation
US FDA Pregnancy Category of Lactulose is B. Studies show that Lactulose has no adverse effects. Decisions regarding use during pregnancy and lactation must be made by a registered physician.
PrecautionsAndWarnings
Avolac should be administered with care to patients who are intolerant to Avolac. The dose used in the treatment of (pre) coma hepaticum is usually much higher and may need to be taken into consideration for diabetics.
OverdoseEffects
There have been no reports of accidental overdosage. In the event of acute overdosage, it is expected that diarrhea and abdominal cramps would be the major symptoms.
TherapeuticClass
Osmotic purgatives
StorageConditions
Keep in a dry place away from light and heat. Keep out of the reach of children.
ChemicalStructure
- MolecularFormula: C12H22O11
- ChemicalStructureImageURL: https://medex.com.bd/storage/res/g-res-653-lactulose-chemical-structure-LBdJlB1MefGyTS21429X.svg
CommonlyAskedQuestions
- What is the use of Avolac 3.35 gm/5 ml Solution?
- At what frequency do I need to use Avolac 3.35 gm/5 ml Solution?
- How long does it take for Avolac 3.35 gm/5 ml Solution to work?
- What is Avolac 3.35 gm/5 ml Solution used for?
- Is Avolac 3.35 gm/5 ml Solution a laxative?
- What are the side effects of taking Avolac 3.35 gm/5 ml Solution?
- Is it okay to take Avolac 3.35 gm/5 ml Solution every day?
- Who should not be given Avolac 3.35 gm/5 ml Solution?
- What if I take more than the recommended dose of Avolac 3.35 gm/5 ml Solution?