Appras 5 mg (Tablet)

Unit Price: ৳ 14.00 (1 x 10: ৳ 140.00)
Strip Price: ৳ 140.00

Medicine Details

Category Details
Generic Prasugrel hydrochloride
Company Unimed unihealth pharmaceuticals ltd
Also available as
Appras 10 mg tablet

Indications

  • Reduce rate of thrombotic cardiovascular events
  • Patients with acute coronary syndrome
  • Unstable angina or non-ST-elevation myocardial infarction
  • ST-elevation myocardial infarction
  • Managed with percutaneous coronary intervention
  • Stent thrombosis

Pharmacology

  • Inhibitor of platelet activation and aggregation
  • Irreversible binding to P2Y12 class of ADP receptors

Dosage & Administration

  • Oral loading dose of 60 mg
  • Maintenance dose of 10 mg once daily
  • Consider 5 mg in patients <60 kg
  • Take with or without food
  • Co-administration with daily aspirin

Interaction

  • Increased risk of bleeding with warfarin
  • Increased risk of bleeding with NSAIDs
  • Can be administered with aspirin, heparin, GPIIb/IIIa inhibitors, statins, drugs that elevate gastric pH

Contraindications

  • Active pathological bleeding
  • History of transient ischemic attack or stroke

Side Effects

  • Bleeding
  • Thrombotic thrombocytopenic purpura
  • Other side effects (headache, back pain, dyspnea, nausea, hypertension, bradycardia, rash)

Pregnancy & Lactation

  • No adequate studies in pregnant women
  • No evidence of fetal harm in animal studies
  • Unknown excretion in human milk

Precautions & Warnings

  • Increased risk of bleeding in CABG
  • Risk of stent thrombosis, MI, and death upon discontinuation

Use in Special Populations

  • Pediatric use not established
  • Increased risk of fatal bleeding events in patients >75 years
  • No dosage adjustment for renal impairment
  • No dosage adjustment for mild to moderate hepatic impairment

Overdose Effects

  • Lethality observed at high doses
  • Platelet transfusion may restore clotting ability
  • Dialysis may not remove active metabolite

Therapeutic Class

  • Anti-platelet drugs

Storage Conditions

  • Store in dry place
  • Away from light and heat
  • Keep out of reach of children

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