Prazolok 1 mg (Tablet)
Unit Price: ৳ 4.00 (3 x 10: ৳ 120.00)
Strip Price: ৳ 40.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Prazosin hydrochloride |
| Company | Square pharmaceuticals plc |
| Also available as |
Indications
- Treatment of essential (primary) hypertension
- Treatment of secondary hypertension
- Treatment of left ventricular failure
- Treatment of Raynaud's phenomenon and Raynaud's disease
- Adjunct treatment for urinary obstruction caused by benign prostatic hyperplasia
Pharmacology
- Causes decrease in total peripheral vascular resistance
- Selective inhibition of postsynaptic alpha-1-adrenoreceptors in vascular smooth muscle
- Lowering of blood pressure in supine and standing positions
- Reduction in left ventricular filling pressure
- Augmentation of cardiac output
Dosage & Administration
- Initiation with low starting dose
- Adjustment of dosage based on patient's response
- Titration according to patient's clinical response
- Dosage range from 0.5 mg to 20 mg for hypertension
- Usual starting dose of 0.5 mg for left ventricular failure, Raynaud's phenomenon, and benign prostatic hyperplasia
- Dosage form of extended-release tablets
Interaction
- No adverse drug interactions observed with cardiac glycosides, hypoglycemic agents, tranquilizers and sedatives, antiarrhythmic agents, analgesics, antipyretics, and anti-inflammatory agents
Contraindications
- Known sensitivity to quinazolines
Side Effects
- Dizziness
- Headache
- Drowsiness
- Palpitations
- Nausea
- Vomiting
- Diarrhea
- Constipation
- Abdominal discomfort
- Liver function abnormalities
- Edema
- Orthostatic hypotension
- Dyspnea
- Faintness
Pregnancy & Lactation
- No teratogenic effects observed in animal testing
- Excretion in small amounts in human milk
Precautions & Warnings
- Postural hypotension at initiation
- Monitoring of blood pressure during initial administration
- Caution in patients already taking medication known to lower blood pressure
Use in Special Populations
- Not recommended for children under the age of 12 years
- Not recommended in the treatment of left ventricular failure due to mechanical obstruction
- Efficacy not established in patients with left ventricular failure due to recent myocardial infarction
Overdose Effects
- Support of the cardiovascular system in case of hypotension
- Monitoring and support of renal function
Therapeutic Class
- Alpha adrenoceptor blocking drugs
Storage Conditions
- Keep away from light and moisture
- Store below 30°C