Isolac 3.35 gm/5 ml (Oral Solution)

100 ml bottle: ৳ 140.00

Medicine Details

Category Details
Generic Lactulose
Company Concord pharmaceuticals ltd

Title

  • Isolac 3.35 gm/5 ml Oral Solution

Categories

  • Medicine
  • Healthcare
  • Digestive Health
  • Laxatives

Indications

  • Constipation
  • Intestinal flora disturbances
  • Increased blood ammonia levels

Description

A hyperosmolar laxative used for effective treatment of constipation. Non-absorbable disaccharide draws water into the bowel, promotes soft stool, and accelerates bowel motion.

Pharmacology

Lactulose is a synthetic disaccharide metabolized in the colon by saccharolytic bacteria, producing low molecular weight organic acids, lowering pH, and retaining water by an osmotic effect.

Dosage & Administration

  • Constipation:
    • Adults:
      • 3-6 teaspoons daily initially
      • 1½-6 teaspoons daily in long-term therapy
    • Children (up to 14 years):
      • 3 teaspoons daily initially
      • 1-2 teaspoons daily in long-term therapy
    • Infants and toddlers:
      • 1-2 teaspoons daily initially
      • 1 teaspoon daily in long-term therapy
  • Damaged Intestinal Flora:
    • Adults:
      • 1-2 teaspoons daily
    • Children:
      • 1 teaspoon daily
  • Reduction of Blood Ammonia Level:
    • Hyper-ammoniemia in Hepatopathy: Maximum 18-30 teaspoons daily
    • Portal Systemic Encephalopathy: Hourly doses of 6-9 teaspoons may be used

Interaction

  • No significant drug interactions; glycosidic effect of cardiac glycosides intensified by potassium deficiency

Contraindications

  • Hypersensitivity to galactose or lactose
  • Galactose-free diet
  • Gastro-cardial symptom complex
  • Suspected intestinal obstruction

Side Effects

  • Flatulence
  • Cramps
  • Abdominal discomfort
  • Diarrhoea in overdose
  • Loss of electrolytes, primarily potassium in abuse

Pregnancy & Lactation

US FDA Pregnancy Category B. No adverse effects observed, decision to use during pregnancy and lactation by registered physician.

Precautions & Warnings

  • Administer with care to intolerant patients
  • Higher dose consideration for (pre)coma hepaticum in diabetics

Overdose Effects

No reports of accidental overdosage. Expected symptoms include diarrhoea and abdominal cramps.

Therapeutic Class

Osmotic purgatives

Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.

Chemical Structure

  • Molecular Formula: C12H22O11
  • Chemical Structure Image: https://medex.com.bd/storage/res/g-res-653-lactulose-chemical-structure-LBdJlB1MefGyTS21429X.svg

Commonly Asked Questions

  • Uses: Treatment of constipation and reduction of blood ammonia levels in liver disease
  • Frequency of Use: Once a day for constipation and three or four times a day for liver disease
  • Onset of Action: 2-3 days for constipation relief
  • Expected Side Effects:
    • Diarrhea
    • Flatulence
    • Nausea
    • Vomiting
    • Abdominal pain
    • Occurrence due to high dose
  • Duration of Use: As advised by the doctor, up to a week for constipation
  • Inapplicability: Patients allergic or intolerant to lactose
  • Overdose Effects: Abdominal pain, electrolyte imbalance, and diarrhea

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