Pregalex 50 mg (Capsule)
Unit Price: ৳ 11.03 (3 x 10: ৳ 330.90)
Strip Price: ৳ 110.30
Medicine Details
| Category | Details |
|---|---|
| Generic | Pregabalin |
| Company | Sharif pharmaceuticals ltd |
| Also available as |
Indications
- Neuropathic pain associated with diabetic peripheral neuropathy (DPN)
- Postherpetic neuralgia (PHN)
- Adjunctive therapy for the treatment of partial-onset seizures in patients 1 month of age and older
- Fibromyalgia
- Neuropathic pain associated with spinal cord injury
Pharmacology
- Structural derivative of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA)
- Binds with high affinity to the alpha2-delta site in central nervous system tissues
Dosage
- Maximum recommended dose of Pregabalin is 100 mg three times a day (300 mg/day) in patients with creatinine clearance of at least 60 ml/min
- Dosing should begin at 50 mg three times a day (150 mg/day)
- Recommended dose of Pregabalin for postherpetic neuralgia is 75 to 150 mg two times a day or 50 to 100 mg three times a day (150 to 300 mg/day)
- Recommended dose of Pregabalin for fibromyalgia is 300 to 450 mg/day
- Maximum recommended dose of Pregabalin CR capsule is 330 mg once daily
Administration
- Pregabalin is taken in oral route
- Pregabalin CR tablet should be administered after an evening meal
- Should be swallowed whole and should not be split, crushed or chewed
Interaction
- Unlikely to be involved in significant pharmacokinetic drug interactions
Contraindications
- Contraindicated in patients with known hypersensitivity to Pregabalin or any of its components
Side Effects
- Dizziness
- Somnolence
- Dry mouth
- Edema
- Blurred vision
- Weight gain
- Difficulty with concentration/attention
- Increased weight and increased appetite (in pediatric patients)
Pregnancy & Lactation
- No adequate and well-controlled studies in pregnant women
- Small amounts detected in the milk of lactating women
- Breastfeeding not recommended due to potential risk of tumorigenicity
Precautions & Warnings
- Angioedema can occur and may be associated with life threatening respiratory compromise
- Increase the risk of suicidal thoughts or behavior
- Respiratory depression may occur when used with concomitant CNS depressants
- May cause dizziness and somnolence and impair ability to drive or operate machinery
- Increased seizure frequency or other adverse reactions may occur if Pregalex is rapidly discontinued
Use in Special Populations
- Safety and effectiveness in pediatric patients have not been established
- Safety and effectiveness in pediatric patients below the age of 1 month have not been established
Overdose Effects
- Reduced consciousness
- Depression/anxiety
- Confusional state
- Seizures
- Heart block
- General supportive care of the patient is indicated
Therapeutic Class
- Adjunct anti-epileptic drugs
- Primary anti-epileptic drugs
Storage Conditions
- Keep in a cool & dry place (below 30°C)
- Protected from light & moisture
- Keep out of the reach of children
Chemical Structure
- Molecular Formula: C8H17NO2
Common Questions about Pregalex 50 mg Capsule
- First-line treatment for neurotic pain, shingles, seizures, and fibromyalgia
- To be taken till the time improvement in health conditions is observed
- Should be taken after food in a prescribed dosage
- Instructions for the storage and disposal
- Works in different ways for different diseases
- Depends on the condition for which it is consumed
- Should not be stopped abruptly
- Can be used with Diazepam
- May cause weight gain
- Quick Tips for usage and side effects