Phensilex 5 mg/5 ml (Oral Solution)
60 ml bottle: ৳ 10.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Promethazine hydrochloride |
| Company | Aztec pharmaceuticals ltd |
Indications
- Potent long-acting antihistamine
- Anti-emetic effect
- Sedative/calming effects
- Treatment of allergic conditions
- Sensitization reactions
- Anaphylactic reactions
- Allergic rhinitis
- Urticaria
- Insomnia
- Pre-operative sedation
- Paediatric sedative
Pharmacology
- Blocks postsynaptic mesolimbic dopaminergic receptors
- Exhibits α-adrenergic blocking effect
- Depresses release of hypothalamic and hypophyseal hormones
- Competes with histamine for the H1-receptor
- Muscarinic blocking effect
- Reduces stimuli to brainstem reticular system
Dosage & Administration
- Initial dose of one 25 mg tablet at night for adults
- Increased dosage to two or three 25 mg tablets if necessary
- Different dosage for children
- Elixir containing 5 mg/5 ml for children
- Specific doses for antihistamine and sedative effects
Interaction
- Enhancement of anticholinergic agents
- Interference with immunologic urine pregnancy tests
- Discontinuation before skin tests using allergen extracts
Contraindications
- Not for children less than two years of age
- Hypersensitivity to promethazine or excipients
- Not for patients in coma or suffering from CNS depression
- Avoid in patients taking monoamine oxidase inhibitors
Side Effects
- Nervous system disorders
- Neuroleptic Malignant Syndrome
- Allergic reactions
- Photosensitivity reaction
- Anorexia
- Gastrointestinal discomfort
- Blurred vision
- Blood dyscrasias
- Urinary retention
- Psychiatric disorders
- Cardiac disorders
- Hypotension
- Jaundice
- Tiredness
- Case reports of promethazine abuse
Pregnancy & Lactation
- Epidemiological evidence for safety in pregnancy
- Not recommended in the two weeks prior to delivery
- Excreted in breastmilk
- Risks of neonatal irritability and excitement
Precautions & Warnings
- Avoid in children and adolescents with signs of Reye's syndrome
- May thicken or dry lung secretions
- Use with caution in patients with various conditions
Overdose Effects
- Symptoms of severe overdose
- Excitation, ataxia, incoordination, athetosis, hallucinations
- Drowsiness, coma, convulsions
- Tachycardia
- Cardiorespiratory depression
Therapeutic Class
- Anti-emetic drugs
- Miscellaneous sedatives & hypnotics
- Sedating anti-histamine
Storage Conditions
- Protection from light
- Not for use after expiry date
- Keep out of the reach of children
- Dispensed only on the prescription of a registered physician