Phenergan 10 mg (Tablet)
Unit Price: ৳ 0.68 (50 x 10: ৳ 340.00)
Strip Price: ৳ 6.80
Medicine Details
| Category | Details |
|---|---|
| Generic | Promethazine hydrochloride |
| Company | Synovia pharma plc |
| Also available as |
Indications
- Potent long-acting antihistamine with additional anti-emetic and sedative/calming effects.
- Indicated in symptomatic treatment of allergic conditions of the respiratory tract and skin.
- Sensitization reactions to drug or foreign proteins, anaphylactic reactions.
- For sedation, allergic rhinitis, urticaria and insomnia.
- As an adjunct in pre-operative sedation in surgery and obstetrics.
- As a paediatric sedative
Pharmacology
- Phenothiazine derivative
- Blocks postsynaptic mesolimbic dopaminergic receptors
- Exhibits strong α-adrenergic blocking effect
- Competes with histamine for the H1-receptor
- Reduces stimuli to the brainstem reticular system
- Well absorbed from the gastrointestinal tract
- Clinical effects apparent within 20 minutes after oral administration
- Generally lasts four to six hours
- Metabolized by the liver to a variety of compounds
Dosage & Administration
- Initial dose one 25 mg tablet at night
- May be increased to two or three 25 mg tablets at night if necessary
- Starting dosage for children elixir containing 5 mg/5 ml
- As an antihistamine in allergy for children of 2-5 years: 5-15 mg; children of 5-10 years: 10-25 mg
- As a sedative for children of 2-5 years: 15-20 mg; children of 5-10 years: 20-25 mg
Interaction
- May enhance the action of any anticholinergic agent, tricyclic antidepressant, sedative or hypnotic
- May interfere with immunologic urine pregnancy tests to produce false-positive or false-negative results
- Should be discontinued at least 72 hours before the start of skin tests using allergen extracts as it may inhibit the cutaneous histamine response thus producing false-negative results
Contraindications
- Contraindicated for use in children less than two years of age
- Hypersensitivity to promethazine or to any of the excipients
- Should not be used in patients who are in a coma or suffering from CNS depression of any cause
- Should be avoided in patients who have been taking monoamine oxidase inhibitors within the previous 14 days
Side Effects
- Neuroleptic Malignant Syndrome
- Anticholinergic effects and confusion
- Somnolence, dizziness, headaches
- Allergic reactions, including urticaria, rash, pruritus, and anaphylaxis
- Photosensitivity reaction
- Anorexia
- Epigastric discomfort, dry mouth
- Blurred vision
- Blood dyscrasias including hemolytic anemia, agranulocytosis
- Urinary retention
- Infants, newborns and premature are susceptible to the anticholinergic effects of promethazine
- Palpitations, arrhythmias
- Hypotension
- Jaundice
- Tiredness
Pregnancy & Lactation
- Epidemiological evidence for the safety of promethazine in pregnancy
- Animal studies have shown no hazard
- Should not be used in pregnancy unless the physician considers it essential
- Not recommended in the two weeks prior to delivery
- Excreted in breastmilk
- Risks of neonatal irritability and excitement
Precautions & Warnings
- Avoided in children and adolescents with signs and symptoms suggestive of Reye’s syndrome
- May thicken or dry lung secretions and impair expectoration
- Use with caution in patients with asthma, bronchitis or bronchiectasis
- Use with care in patients with severe coronary artery disease
- Use with care in patients with narrow angle glaucoma
- Use with care in patients with epilepsy
- Use with care in patients with hepatic insufciency
- Use with care in patients with renal insufciency
- Exercise caution in patients with bladder neck obstruction
- Exercise caution in patients with pyloro-duodenal obstruction
Overdose Effects
- Symptoms of severe overdose are variable
- Characterised in children by various combinations of excitation, ataxia, incoordination, athetosis and hallucinations
- Adults may become drowsy and lapse into coma
- Convulsions may occur in both adults and children
- Tachycardia may develop
- Cardiorespiratory depression is uncommon
- Possible to induce vomiting with ipecacuanha despite the antiemetic effect of promethazine
- Treatment is otherwise supportive with attention to maintenance of adequate respiratory and circulatory status
- Convulsions should be treated with diazepam or other suitable anticonvulsant
Therapeutic Class
- Anti-emetic drugs
- Miscellaneous sedatives & hypnotics
- Sedating Anti-histamine
Storage Conditions
- Protect from light
- Do not use later than the date of expiry
- To be dispensed only on the prescription of a registered physician