Prozen 25 mg (Tablet)
Unit Price: ৳ 0.42 (50 x 10: ৳ 210.00)
Strip Price: ৳ 4.20
Medicine Details
| Category | Details |
|---|---|
| Generic | Promethazine hydrochloride |
| Company | Zenith pharmaceuticals ltd |
Indications
- Long-acting antihistamine
- Anti-emetic effects
- Sedative/calming effects
- Treatment of allergic conditions of respiratory tract and skin
- Sensitization reactions
- Allergic rhinitis
- Urticaria
- Insomnia
- Pre-operative sedation in surgery
- Paediatric sedative
Pharmacology
- Phenothiazine derivative
- Blocks postsynaptic mesolimbic dopaminergic receptors
- Alpha-adrenergic blocking effect
- Reduces release of hypothalamic and hypophyseal hormones
- Competes with histamine for H1-receptor
- Muscarinic blocking effect
- Reduces stimuli to brainstem reticular system
- Well absorbed from gastrointestinal tract
- Clinical effects within 20 minutes after oral administration
- Metabolized by liver to various compounds
Dosage & Administration
- Initial dose for adults: 25 mg tablet at night
- Maximum adult dose: three 25 mg tablets at night
- Elderly: No specific dosage recommendations
- Children: Elixir containing 5 mg/5 ml
- Antihistamine dosage for children of 2-10 years
- Sedative dosage for children of 2-10 years
Interaction
- Enhances action of anticholinergic agents
- May interfere with immunologic urine pregnancy tests
- Should be discontinued before skin tests using allergen extracts
Contraindications
- Contraindicated in children less than two years old
- Hypersensitivity to promethazine or excipients
- Not for use in patients in coma or with CNS depression
- Avoid in patients who have taken monoamine oxidase inhibitors within previous 14 days
Side Effects
- Nervous system disorders
- Immune system disorders
- Skin and subcutaneous tissue disorders
- Metabolism and nutrition disorders
- Gastrointestinal disorders
- Eye disorders
- Blood and lymphatic system disorders
- Renal and urinary disorders
- Psychiatric disorders
- Cardiac disorders
- Vascular disorders
- Hepatobiliary disorders
- General disorders and administration site conditions
- Cases of promethazine abuse reported
Pregnancy & Lactation
- Epidemiological evidence for safety in pregnancy
- Not recommended in two weeks prior to delivery
- Risks of prolonged neurological disturbances in infant if given in high doses during late pregnancy
- Excreted in breastmilk
- Risks of neonatal irritability and excitement
Precautions & Warnings
- Avoid in children and adolescents with signs suggestive of Reye’s syndrome
- May thicken or dry lung secretions
- Use with caution in patients with asthma, bronchitis, or bronchiectasis
- Use with care in patients with severe coronary artery disease, narrow angle glaucoma, epilepsy, hepatic or renal insufficiency
- Caution in patients with bladder neck obstruction or pyloro-duodenal obstruction
Overdose Effects
- Symptoms of severe overdose
- Variable symptoms in children
- Drowsiness or coma in adults
- Possible convulsions in both adults and children
- Tachycardia
- Cardiorespiratory depression uncommon
- Inducing vomiting with ipecacuanha
- Gastric lavage may be used
- Supportive treatment for respiratory and circulatory status
- Treatment for convulsions with diazepam or anticonvulsant
Therapeutic Class
- Anti-emetic drugs
- Miscellaneous sedatives & hypnotics
- Sedating Anti-histamine
Storage Conditions
- Protect from light
- Do not use after expiry date
- Keep out of reach of children
- Dispensed only on prescription