Dexpoten Plus (20 mg+10 mg+2.5 mg)/5 ml (Syrup)

Indications

• Temporarily relieves symptoms of common cold
• Temporarily relieves symptoms of hay fever
• Temporarily relieves symptoms of upper respiratory allergies
• Relieves cough due to minor throat irritation
• Relieves cough due to bronchial irritation
• Relieves runny nose
• Relieves sneezing
• Relieves itching of the nose or throat
• Relieves itchy, watery eyes
• Relieves nasal congestion
• Reduces swelling of nasal passages

Pharmacology

• Contains antitussive agent
• Contains decongestant agent
• Contains antihistamine agent
• Dextromethorphan has central action on cough center
• Phenylephrine shrinks blood vessels in nasal passage
• Triprolidine provides relief from histamine-triggered conditions
• Dextromethorphan is non-narcotic
• Dextromethorphan has little sedative activity

Dosage

• 1 teaspoonful (5 ml) every 4 hours for adults & children 12+
• ½ teaspoonful (2.5 ml) every 4 hours for children 6 to under 12
• Caution for children 2 to 6 years
• Not for children below 2 years

Administration

• Can be taken with or without food
• Recommended to take with food if it causes upset stomach
• Liquid doses should be carefully measured
• Use the provided measuring device

Interaction

• Serious drug interaction with certain MAO inhibitors
• Avoid concurrent use with certain MAO inhibitors
• Exercise caution with antihistamines applied to the skin
• Exercise caution with antispasmodics
• Exercise caution with beta blockers
• Exercise caution with drugs for Parkinson’s disease
• Exercise caution with guanethidine
• Exercise caution with certain inhaled anesthetics
• Exercise caution with methyldopa
• Exercise caution with reserpine
• Exercise caution with scopolamine
• Exercise caution with tricyclic antidepressants
• Exercise caution with anti-seizure drugs
• Exercise caution with medicine for sleep or anxiety
• Exercise caution with muscle relaxants
• Exercise caution with narcotic pain relievers
• Exercise caution with psychiatric medicines

Contraindications

• Avoid in patients with liver disease
• Avoid in asthmatic patients
• Contraindicated in patients taking monoamine oxidase inhibitors
• Contraindicated within 2 weeks from stopping MAO inhibitors
• Avoid in known hypersensitivity to specific ingredients
• Contraindicated during acute asthma attacks
• Avoid in patients with severe hypertension
• Avoid in patients with severe coronary artery disease

Side Effects

• May cause drowsiness
• May cause dizziness
• May cause constipation
• May cause GIT discomfort
• May cause transient hypertension
• May cause dry mouth
• May cause restlessness
• May cause palpitations
• May cause allergic reactions
• May cause thickening of bronchial secretions
• May cause toxic psychosis
• May cause blood dyscrasia

Pregnancy & Lactation

• Best avoided in pregnancy
• Best avoided in lactation

Precautions & Warnings

• May cause drowsiness
• Avoid driving or operating machinery if affected
• Avoid alcoholic drinks while using this medication
• Use with caution in patients with epilepsy
• Use with caution in patients with prostatic hypertrophy
• Use with caution in patients with glaucoma
• Use with caution in patients with hepatic disease
• Use with caution in patients with hypertension
• Use with caution in patients with heart disease
• Use with caution in patients with diabetes
• Use with caution in patients with hyperthyroidism
• Use with caution in patients with stenosing peptic ulcer
• Use with caution in patients with pyloro-duodenal obstruction
• Use with caution in patients with bladder neck obstruction
• Consult a physician if symptoms do not improve within one week
• Consult a physician if accompanied by high fever

Overdose Effects

• Hospital admission strongly advised in cases of overdose
• Overdose may produce respiratory depression
• Overdose may produce paranoid psychosis
• Overdose may produce delusions
• Overdose may produce hallucinations
• Overdose may produce convulsions
• Treatment may include emptying the stomach by aspiration or gastric lavage
• Nervous stimulation and convulsions should be treated with a sedative
• Severe overdose may produce hypertension
• Severe overdose may produce associated reflex bradycardia
• Treatment measures may include early gastric lavage
• Treatment measures may include symptomatic and supportive measures
• Hypertensive effects may be treated with an alpha-receptor blocking agent
• Bradycardia may be treated with atropine

Therapeutic Class

• Combined cough suppressants

Storage Conditions

• Keep out of the reach of children
• Keep in a cool & dry place
• Protect from light

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