Quetinil 100 mg (Tablet)
Unit Price: ৳ 10.50 (5 x 10: ৳ 525.00)
Strip Price: ৳ 105.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Quetiapine fumarate |
| Company | Albion laboratories limited |
| Also available as |
Indications
- Treatment of Acute and chronic psychoses
- Treatment of schizophrenia
- Treatment of Bipolar Disorder
- Treatment of manic episodes
- Treatment of depressive episodes
- Maintenance treatment of bipolar I disorder
- Prevention of recurrence of manic, depressive or mixed episodes
Pharmacology
- Belongs to a chemical class, the dibenzothiazepine derivatives
- Antagonist at multiple neurotransmitter receptors
- Antagonist at serotonin 5HT1A and 5HT2 receptors
- Antagonist at dopamine D1 and D2 receptors
- Antagonist at histamine H1 receptors
- Antagonist at adrenergic alpha1 and alpha2 receptors
- Unknown mechanism of action
Dosage & Administration
- Administered twice daily
- Total daily dose for the first four days of therapy
- Dosage titration to the usual effective dose range
- Dosage adjustments based on clinical response and tolerability
- Usual effective dose range
- Usual dose for manic episodes associated with bipolar disorder
- Usual dose for depressive episodes associated with bipolar disorder
- Usual dose for maintenance treatment of bipolar I disorder
Interaction
- Caution with medicines known to cause electrolyte imbalance
- Caution with medicines known to increase QT interval
- Co-administration with thioridazine or carbamazepine
- Co-administration with microsomal enzyme inducers like phenytoin
Contraindications
- Contra-indicated in patients hypersensitive to Quetiapine
Side Effects
- Somnolence
- Dizziness
- Dry mouth
- Withdrawal (discontinuation) symptoms
- Elevations in serum triglyceride levels
- Elevations in total cholesterol
- Weight gain
- Decreased haemoglobin
- Extrapyramidal symptoms
Pregnancy & Lactation
- Safety and efficacy during human pregnancy not established
- Use during pregnancy if benefits justify potential risks
- Lowest possible dose and shortest duration for use in pregnancy
- Unknown excretion into human milk
- Advice for breastfeeding women
Precautions & Warnings
- Increased risk of suicidal thoughts and self-harm
- Caution in patients with known cardiovascular disease
- Caution in patients with predisposition to hypotension
- Caution in treating patients with a history of seizures
- Consider dose reduction or discontinuation if tardive dyskinesia appears
- Discontinue and provide appropriate medical treatment for neuroleptic malignant syndrome
- Exercise caution in prescribing to patients with cardiovascular disease or family history of QT prolongation
- Rare reports of severe neutropenia
- Observations of increases in blood glucose and hyperglycaemia
Use in Special Populations
- Caution in use for the elderly
- Lower dose and slower titration in the elderly
- Not indicated for use in children and adolescents below 18 years of age
Overdose Effects
- Survival reported in acute overdoses up to 30 grams
- No specific antidote available
- Consideration of multiple drug involvement in severe intoxication
- Intensive care procedures recommended
- Close medical supervision and monitoring
Therapeutic Class
- Atypical neuroleptic drugs
Storage Conditions
- Keep out of sight and reach of children
- Do not use after expiry date
- Store in a cool and dry place away from light