Rabepes 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 8.00 (5 x 10: ৳ 400.00)
Strip Price: ৳ 80.00

Medicine Details

Category Details
Generic Rabeprazole sodium
Company Beacon pharmaceuticals plc
Also available as
Rabepes mups 20 mg tablet Rabepes 10 mg tablet

Indications

  • Treatment of active duodenal ulcer
  • Treatment of active benign gastric ulcer
  • Treatment of symptomatic erosive or ulcerative gastro-esophageal reflux disease (GERD)
  • Maintenance therapy for gastro-esophageal reflux disease
  • Symptomatic treatment of moderate to very severe GERD
  • Treatment of Zollinger-Ellison Syndrome
  • Eradication of Helicobacter pylori in patients with peptic ulcer disease

Pharmacology

  • Inhibits gastric acid secretion by suppressing H+/K+-ATPase
  • Characterized as a gastric proton-pump inhibitor

Dosage

  • Recommended oral dose for active duodenal ulcer and active benign gastric ulcer is 20 mg once daily
  • Recommended oral dose for erosive or ulcerative GERD is 20 mg daily for 4-8 weeks
  • Maintenance dose for GERD is 20 mg or 10 mg once daily
  • Treatment of pediatric GERD varies based on weight and age
  • Recommended starting dose for Zollinger-Ellison Syndrome is 60 mg daily
  • Recommended eradication therapy includes rabeprazole, clarithromycin, and amoxicillin

Administration

  • Tablets should be taken in the morning before eating
  • Tablets should be swallowed whole, not chewed or crushed

Interaction

  • May interact with pH-dependent compounds like ketoconazole and itraconazole
  • No interaction with liquid antacids observed
  • Should not be co-administered with atazanavir

Contraindications

  • Contraindicated in individuals with hypersensitivity to the active substance or excipients
  • Contraindicated in pregnancy and breastfeeding

Side Effects

  • Common side effects include headache, diarrhea, abdominal pain, vomiting, constipation, dry mouth, changes in appetite, muscle pain, drowsiness, dizziness

Pregnancy & Lactation

  • US FDA pregnancy category 'C'
  • No adequate and well-controlled studies in pregnant women
  • Rabeprazole is likely excreted in human milk

Precautions & Warnings

  • Symptomatic response to therapy does not exclude malignancy
  • Regular surveillance for patients on long-term treatment
  • May increase risk of fractures in high doses and long durations
  • Risk of hypersensitivity reactions with other proton pump inhibitors
  • Risk of blood dyscrasias and hepatic enzyme abnormalities

Use in Special Populations

  • No dosage adjustment needed for renal or hepatic impairment
  • Not recommended for use in children due to lack of data

Overdose Effects

  • Maximum established exposure up to 160 mg once daily
  • Effects are generally minimal and reversible without specific antidote
  • Treatment should be symptomatic and supportive

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Store below 30°C, away from light and moisture
  • Keep out of the reach of children

Chemical Structure

  • Molecular formula: C18H21N3O3S

Common Questions about Rabepes 20 mg Capsule

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