Unirab 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 5.00 (6 x 10: ৳ 300.00)
Strip Price: ৳ 50.00

Medicine Details

Category Details
Generic Rabeprazole sodium
Company Concord pharmaceuticals ltd

Indications

  • Active duodenal ulcer
  • Active benign gastric ulcer
  • Symptomatic erosive or ulcerative gastro-esophageal reflux disease (GERD)
  • Gastro-esophageal Reflux Disease Long-term Management (GERD Maintenance)
  • Symptomatic treatment of moderate to very severe gastro-esophageal reflux disease (symptomatic GERD)
  • Zollinger-Ellison Syndrome
  • In combination with appropriate antibacterial therapeutic regimens for the eradication of Helicobacter pylori in patients with peptic ulcer disease

Pharmacology

  • Suppression of gastric acid secretion
  • Inhibition of the gastric H+/K+-ATPase enzyme
  • Characterized as a gastric proton-pump inhibitor

Dosage

  • Recommended oral dose of 20mg taken once daily in the morning for active duodenal ulcer and active benign gastric ulcer
  • Recommended oral dose of 20mg taken once daily for four to eight weeks for erosive or ulcerative GERD
  • Maintenance dose of 20mg or 10mg once daily for long-term GERD management
  • 10mg once daily for symptomatic treatment of moderate to very severe GERD
  • Treatment regimen for pediatric patients 1 to 11 years old based on weight and response
  • Adult starting dose of 60mg once daily for Zollinger-Ellison Syndrome with potential titration to 120mg/day

Administration

  • To be taken in the morning before eating
  • Tablets should not be chewed or crushed, but swallowed whole

Interaction

  • Potential interaction with pH-dependent absorption compounds
  • Possible decrease in antifungal plasma levels when co-administered with specific medications
  • Absorption of atazanavir is pH-dependent and should not be co-administered with rabeprazole

Contraindications

  • Hypersensitivity to active substance or excipients
  • Contraindicated in pregnancy and breastfeeding

Side Effects

  • Well-tolerated overall with common side effects like headache, diarrhea, abdominal pain, vomiting, dry mouth, dizziness
  • Rare cases of blood dyscrasias and hepatic enzyme abnormalities reported

Pregnancy & Lactation

  • FDA pregnancy category 'C'
  • Excretion in human milk, decision should be made regarding continuation based on importance to mother

Precautions & Warnings

  • Symptomatic response does not exclude malignancy
  • Surveillance for long-term treatment patients
  • Modest increase in fracture risk with prolonged use, especially in elderly
  • Risk of cross-hypersensitivity reactions
  • Caution in severe hepatic dysfunction patients
  • Possible hypomagnesaemia and vitamin B12 absorption reduction
  • Association with subacute cutaneous lupus erythematosus and interference with certain laboratory tests

Use in Special Populations

  • No dosage adjustment for renal or hepatic impairment
  • Not recommended for pediatric use

Overdose Effects

  • Effects generally minimal and reversible without intervention
  • No specific antidote known, treatment should be symptomatic and supportive

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Store below 30°C, away from light and moisture, keep out of reach of children

Chemical Structure

  • Molecular Formula: C18H21N3O3S

Common Questions

  • Usage, side effects, dosage, pregnancy considerations
  • Potential bone problems with long-term use
  • Interaction with vitamin D

General Information

  • Provision of relief for various gastric conditions
  • Avoidance of chewing or crushing tablets
  • Caution in specific patient populations

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