P Lac 3.35 gm/5 ml (Oral Solution)

100 ml bottle: ৳ 93.12

Medicine Details

Category Details
Generic Lactulose
Company Pharmadesh laboratories ltd

Title

P Lac 3.35 gm/5 ml Oral Solution

Categories

  • Medicine
  • Laxative
  • Digestive Health

Description

P Lac is a hyperosmolar laxative used for the effective treatment of constipation. It is a non-absorbable disaccharide that draws water into the bowel, causing distention through fluid accumulation, promoting soft stool, and accelerating bowel motion.

Indications

  • Constipation (Chronic Constipation)
  • Intestinal flora disturbances
  • Increased blood ammonia levels (hyper ammoniemia in hepatopathy, portal-systemic encephalopathy)

Pharmacology

Lactulose is a synthetic disaccharide metabolized in the colon by saccharolytic bacteria, producing organic acids, lowering the pH of colon contents, promoting water retention by an osmotic effect, and increasing peristaltic activity. It is minimally absorbed.

DosageAndAdministration

  • Constipation:
    • Adults: Initially 3-6 teaspoons daily, long-term therapy 1½-6 teaspoons daily
    • Children up to 14 years: Initially 3 teaspoons daily, long-term therapy 1-2 teaspoons daily
    • Infants and toddlers: Initially 1-2 teaspoons daily, long-term therapy 1 teaspoon daily
  • DamagedIntestinalFlora:
    • Adults: 1-2 teaspoons daily
    • Children: 1 teaspoon daily
  • ReductionOfBloodAmmoniaLevel:
    • Hyper-ammoniemia in hepatopathy: Up to 18-30 teaspoons daily
    • In portal systemic encephalopathy: Hourly doses of 6-9 teaspoons; dose reduction after achieving laxative effect

Interaction

No significant drug interactions with P Lac. Potassium deficiency may intensify the glycosidic effect of cardiac glycosides.

Contraindications

Hypersensitivity to galactose or lactose, galactose-free diet, gastro-cardial symptom complex, suspected intestinal obstruction

SideEffects

  • Flatulence
  • Cramp
  • Abdominal discomfort (occasional)
  • Diarrhea (overdose)
  • Loss of electrolytes, primarily potassium (overdose/abuse)

PregnancyAndLactation

  • USFDAPregnancyCategory: B
  • Effects: Studies show no adverse effects, physician discretion for use during pregnancy and lactation

PrecautionsAndWarnings

Administer with care to patients intolerant to P Lac. Considerably higher dose may be used in the treatment of (pre) coma hepaticum and may need to be considered for diabetics.

OverdoseEffects

No reports of accidental overdosage; expected symptoms include diarrhea and abdominal cramps.

TherapeuticClass

Osmotic purgatives

StorageConditions

Keep in a dry place away from light and heat. Keep out of the reach of children.

ChemicalStructure

  • MolecularFormula: C12H22O11
  • ChemicalImage: https://medex.com.bd/storage/res/g-res-653-lactulose-chemical-structure-LBdJlB1MefGyTS21429X.svg

CommonlyAskedQuestions

  • Use: Treat constipation, reduce ammonia in liver disease
  • Frequency: Consume once a day for constipation, 3-4 times a day for liver disease
  • TimeToWork: 2-3 days for benefits; consult doctor if constipated after 3 days
  • SideEffects: Diarrhea, flatulence, nausea, vomiting, and abdominal pain at high doses
  • DailyUsage: As advised by doctor or up to a week for constipation
  • Contraindication: Patients allergic to or intolerant to lactose should not use
  • Overdose: May cause abdominal pain, electrolyte imbalance, and diarrhea

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