Xorel 20 mg (Tablet (Enteric Coated))

Unit Price: ৳ 4.00 (10 x 10: ৳ 400.00)
Strip Price: ৳ 40.00

Medicine Details

Category Details
Generic Rabeprazole sodium
Company Ibn sina pharmaceuticals ltd
Also available as
Xorel 20 mg capsule Xorel 10 mg tablet Xorel 10 mg capsule Xorel mups 20 mg tablet

Title

  • Xorel Gastro-resistant Tablets

Categories

  • Medicine
  • Gastrointestinal
  • Pharmaceutical

Indications

  • Treatment of active duodenal ulcer
  • Treatment of active benign gastric ulcer
  • Treatment of erosive or ulcerative gastro-esophageal reflux disease (GERD)
  • Long-term management of gastro-esophageal reflux disease (GERD maintenance)
  • Symptomatic treatment of moderate to very severe gastro-esophageal reflux disease (symptomatic GERD)
  • Treatment of Zollinger-Ellison Syndrome
  • Eradication of Helicobacter pylori in patients with peptic ulcer disease

Mode of Action

  • Suppresses gastric acid secretion by inhibiting the gastric H+/K+-ATPase
  • Characterized as a gastric proton-pump inhibitor

Dosage

  • Recommended oral dose for active duodenal ulcer and active benign gastric ulcer is 20 mg once daily in the morning
  • Recommended oral dose for erosive or ulcerative gastro-esophageal reflux disease (GERD) is 20 mg once daily for four to eight weeks
  • Maintenance dose of 20 mg or 10 mg once daily for long-term management of gastro-esophageal reflux disease (GERD maintenance)
  • 10 mg once daily for symptomatic treatment of moderate to very severe gastro-esophageal reflux disease (symptomatic GERD)
  • 5 mg once daily for pediatric patients 1-11 years of age (less than 15 kg)
  • 10 mg once daily for pediatric patients 1-11 years of age (15 kg or more)
  • Recommended adult starting dose for Zollinger-Ellison Syndrome is 60 mg once a day, titrated upwards to 120 mg/day based on individual patient needs
  • Combination therapy for H. pylori eradication: Rabeprazole sodium 20 mg twice daily, clarithromycin 500 mg twice daily, and amoxicillin 1g twice daily for 7 days

Administration

  • Should be taken in the morning, before eating
  • Tablets should not be chewed or crushed, but should be swallowed whole

Interactions

  • May interact with compounds whose absorption is pH dependent
  • Co-administration with ketoconazole or itraconazole may decrease antifungal plasma levels
  • No interaction with liquid antacids observed
  • PPIs, including rabeprazole, should not be co-administered with atazanavir

Contraindications

  • Hypersensitivity to the active substance or any excipients
  • Contra-indicated in pregnancy and during breastfeeding

Side Effects

  • Well-tolerated in both short-term and long-term studies
  • May cause headache, diarrhea, abdominal pain, vomiting, constipation, dry mouth, changes in appetite, muscle pain, drowsiness, dizziness

Pregnancy & Lactation

  • US FDA pregnancy category 'C'
  • No adequate and well-controlled studies in pregnant women
  • Likely to be excreted in human milk

Precautions & Warnings

  • Symptomatic response does not preclude the presence of gastric or esophageal malignancy
  • Patients on long-term treatment should be kept under regular surveillance
  • Proton pump inhibitors may modestly increase the risk of hip, wrist, and spine fracture
  • Risk of cross-hypersensitivity reactions with other proton pump inhibitors or substituted benzimidazoles
  • Reports of blood dyscrasias and hepatic enzyme abnormalities
  • Caution in patients with severe hepatic dysfunction
  • Co-administration with atazanavir not recommended
  • Possible increase in the risk of gastrointestinal infections
  • Risk of severe hypomagnesemia after prolonged treatment
  • Potential reduction in vitamin B12 absorption
  • Rare cases of subacute cutaneous lupus erythematosus associated with PPIs
  • Potential interference with laboratory tests, including increased Chromogranin A level

Use in Special Populations

  • No dosage adjustment necessary for patients with renal or hepatic impairment
  • Not recommended for use in children due to lack of data on safety and efficacy

Overdose Effects

  • Effects generally minimal, representative of the known adverse event profile and reversible without further medical intervention
  • No specific antidote known
  • Extensively protein bound and not dialysable
  • Treatment should be symptomatic and general supportive measures should be utilized

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep below 30°C temperature, away from light & moisture
  • Keep out of the reach of children

Chemical Structure

  • Molecular Formula: C18H21N3O3S

Commonly Asked Questions

  • What is Xorel 20 mg Tablet?
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