Regulose 3.35 gm/5 ml (Oral Solution)
Medicine Details
| Category | Details |
|---|---|
| Generic | Lactulose |
| Company | General pharmaceuticals ltd |
Indications
- Effective treatment approach for constipation
- Treatment of damaged intestinal flora
- Reduction of blood ammonia levels
Description
Non-absorbable disaccharide which draws water into the bowel; causes distention through fluid accumulation, promotes soft stool, and accelerates bowel motion
Pharmacology
Synthetic disaccharide metabolized in the colon by saccharolytic bacteria, producing low molecular weight organic acids, which lowers the pH of the colon contents, promotes the retention of water by an osmotic effect, and increases peristaltic activity
Dosage & Administration
- Adult dosage for chronic constipation: 3-6 tea-spoons initially, 1.5-6 tea-spoons in long-term therapy
- Children dosage for chronic constipation: 3 tea-spoons initially, 1-2 tea-spoons in long-term therapy
- Infants and toddlers dosage for chronic constipation: 1-2 tea-spoons initially, 1 tea-spoon in long-term therapy
- Adult dosage for damaged intestinal flora: 1-2 tea-spoons daily
- Children dosage for damaged intestinal flora: 1 tea-spoon daily
- Maximum dosage for hyper-ammoniemia in hepatopathy: 18-30 tea-spoons daily
- Hourly doses in portal systemic encephalopathy: 6-9 tea-spoons of Lactulose solution
Interaction
No significant drug interactions with Regulose. The glycosidic effect of cardiac glycosides can be intensified by potassium deficiency in abuse
Contraindications
- Hypersensitivity to galactose and/or lactose
- Galactose-free diet
- Gastro-cardial symptom complex
- Suspected intestinal obstruction
Side Effects
- Occasional flatulence, cramp, and abdominal discomfort
- Overdose can result in diarrhea
- Loss of electrolytes, primarily potassium in abuse
Pregnancy & Lactation
US FDA Pregnancy Category B; no adverse effects observed. Decisions regarding use during pregnancy and lactation must be made by a registered physician
Precautions & Warnings
Should be administered with care to patients intolerant to Regulose. The dose used in the treatment of (pre)coma hepaticum is usually much higher and may need to be taken into consideration for diabetics
Overdose Effects
No reports of accidental overdosage. Expected symptoms include diarrhea and abdominal cramps
Therapeutic Class
Osmotic purgatives
Storage Conditions
Keep in a dry place away from light and heat; keep out of the reach of children
Chemical Structure
- Molecular Formula: C12H22O11
- Chemical Structure Image: https://medex.com.bd/storage/res/g-res-653-lactulose-chemical-structure-LBdJlB1MefGyTS21429X.svg
Common Questions
- Use: Treatment of constipation and reducing ammonia in the blood of patients with liver disease
- Frequency of Use: Once a day for constipation, three or four times a day for liver disease
- Time to Work: About 2-3 days to see the benefits of the treatment
- Side Effects: Diarrhea, flatulence, nausea, vomiting, abdominal pain; higher doses can lead to diarrhea and abdominal pain
- Duration of Use: As advised by a doctor or as long as constipation lasts, which may be up to a week
- Patients to Avoid: Patients allergic to or intolerant to lactose
- Overdose Consequences: Abdominal pain, electrolyte imbalance, diarrhea lasting a couple of days
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