Rubee 20 mg (Tablet (Enteric Coated))

Unit Price: ৳ 7.00 (6 x 10: ৳ 420.00)
Strip Price: ৳ 70.00

Medicine Details

Category Details
Generic Rabeprazole sodium
Company Kumudini pharma ltd

Title

Rabee 20 mg Tablet

Categories

  • Gastrointestinal
  • Proton Pump Inhibitor
  • Medication

Description

Rabee Gastro-resistant tablets are indicated for the treatment of active duodenal ulcer, active benign gastric ulcer, symptomatic erosive or ulcerative gastro-esophageal reflux disease (GERD), GERD long-term management, symptomatic treatment of moderate to very severe GERD, Zollinger-Ellison Syndrome, and in combination with antibacterial therapeutic regimens for the eradication of Helicobacter pylori.

ActiveIngredients

  • Rabeprazole sodium

DosageForm

Tablet

DosageStrength

20 mg

Indications

  • Active duodenal ulcer
  • Active benign gastric ulcer
  • Symptomatic erosive or ulcerative GERD
  • GERD long-term management
  • Symptomatic treatment of moderate to very severe GERD
  • Zollinger-Ellison Syndrome
  • Eradication of Helicobacter pylori

Pharmacology

Suppresses gastric acid secretion by inhibiting the gastric H+/K+-ATPase at the secretory surface of the gastric parietal cell.

Dosage

  • ActiveDuodenalUlceAndActiveBenignGastricUlcer: 20 mg once daily in the morning
  • ErosiveOrUlcerativeGERD: 20 mg once daily for 4-8 weeks
  • GERDLongTermManagement: 20 mg or 10 mg once daily
  • SymptomaticTreatmentOfGERD: 10 mg once daily (if symptoms have not resolved, on-demand regimen)
  • PediatricPatientsLessThan15kg: 5 mg once daily for 12 weeks
  • PediatricPatients15kgOrMore: 10 mg once daily for 12 weeks
  • ZollingerEllisonSyndrome: 60-120 mg once daily
  • EradicationOfHPylori: Rabeprazole sodium 20 mg twice daily, clarithromycin 500 mg twice daily and amoxicillin 1g twice daily for 7 days

Administration

Take in the morning, before eating. Swallow whole, not to be chewed or crushed.

Interaction

  • Potential interaction with pH-dependent absorption compounds
  • Co-administration with ketoconazole or itraconazole may decrease antifungal plasma levels
  • No interaction with liquid antacids
  • Atazanavir absorption is pH-dependent, so co-administration with PPIs should be avoided

Contraindications

  • Hypersensitivity to the active substance or excipients
  • Contraindicated in pregnancy and during breastfeeding

SideEffects

  • Headache
  • Diarrhoea
  • Abdominal pain
  • Vomiting
  • Constipation
  • Dry mouth
  • Increased or decreased appetite
  • Muscle pain
  • Drowsiness
  • Dizziness

PregnancyAndLactation

US FDA pregnancy category 'C'. No adequate and well-controlled studies in pregnant women. Likely excreted in human milk.

PrecautionsAndWarnings

  • Symptomatic response does not preclude malignancy
  • Regular surveillance for long-term treatment
  • Potential increased risk of hip, wrist, and spine fracture for long-term high-dose use
  • Risk of cross-hypersensitivity reactions
  • Possible blood dyscrasias and hepatic enzyme abnormalities
  • Caution in severe hepatic dysfunction and co-administration with atazanavir
  • Possible increased risk of gastrointestinal infections
  • Severe hypomagnesemia and influence on vitamin B12 absorption
  • Association with subacute cutaneous lupus erythematosus (SCLE) and interference with laboratory tests

UseInSpecialPopulations

  • No dosage adjustment for renal or hepatic impairment
  • Not recommended for use in children

OverdoseEffects

Effects are generally minimal, reversible without further intervention. No specific antidote known. Symptomatic and general supportive measures should be utilized.

TherapeuticClass

Proton Pump Inhibitor

StorageConditions

Keep below 30°C, away from light & moisture, out of the reach of children

ChemicalStructure

  • MolecularFormula: C18H21N3O3S
  • ChemicalStructureImageURL: https://medex.com.bd/storage/res/g-res-942-rabeprazole-sodium-chemical-structure-atwg0Q4PlndQZhOY9GHX.svg

CommonQuestions

    • Question: What is Rubee 20 mg Tablet?
    • Answer: A proton pump inhibitor that suppresses gastric acid secretion.
    • Question: What is Rubee 20 mg Tablet used for?
    • Answer: Treatment of Duodenal ulcer, Gastric ulcer, GERD, Zollinger-Ellison Syndrome, Helicobacter pylori eradication.
    • Question: What are the side effects of Rubee 20 mg Tablet?
    • Answer: Common side effects include diarrhea, constipation, nausea, vomiting, headache, dizziness, rash, and dry mouth. Serious side effects are rare but can include kidney problems, liver damage, and bone fractures.

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